Aceclofenac

Bezeichnung:Aceclofenac

CAS-Nr89796-99-6

Englisch Name:Aceclofenac

CBNumberCB0402570

SummenformelC16H13Cl2NO4

Molgewicht354.18

MOL-Datei89796-99-6.mol

Aceclofenac physikalisch-chemischer Eigenschaften

Schmelzpunkt	149-153°C
Siedepunkt	486.0±45.0 °C(Predicted)
Dichte	1.455±0.06 g/cm3(Predicted)
RTECS-Nr.	CY1577900
storage temp.	2-8°C
Löslichkeit	Soluble in DMSO
Aggregatzustand	powder
pka	2.60±0.10(Predicted)
Farbe	off-white to light tan
Wasserlöslichkeit	32mg/L(32 ºC)
Merck	14,22
InChIKey	MNIPYSSQXLZQLJ-UHFFFAOYSA-N
CAS Datenbank	89796-99-6(CAS DataBase Reference)
EPA chemische Informationen	Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, carboxymethyl ester (89796-99-6)

Sicherheit

Kennzeichnung gefährlicher	T,N
R-Sätze:	25-36-50/53
S-Sätze:	26-45-60-61
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
HazardClass	6.1
PackingGroup	III
HS Code	29224999

Gefahreninformationscode (GHS)

Aceclofenac Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Aceclofenac is a nonsteroidal antiinflammatory agent with analgesic and antipyretic properties. It is reported to be useful in the treatment of osteoarthritis, rheumatoid arthritis and pain associated with minor surgical procedures. Compared to ketoprofen in the treatment of rheumatoid arthritis, aceclofenac is substantially faster acting.
Chemische Eigenschaften
White Crystalline Solid
Originator
Prodes (Prodesfarma) (Spain)
Verwenden
Aceclofenac is a non-steroidal, anti-inflammatory drug (NSAID) with potent inhibitory activity in several models of inflammation. It is used for the treatment of osteoarthritis and rheumatoid arthritis. It is a Biopharmaceutics classification system class II (BCS class I) drug which has an intermediate half-life of 3-4h and undergoes substantial first pass metabolism. aceclofenac is available either in oral form (tablet) or in topical form (gel).
Verwenden
Labeled Aceclofenac, intended for use as an internal standard for the quantification of Aceclofenac by GC- or LC-mass spectrometry.
Definition
ChEBI: Aceclofenac is a monocarboxylic acid that is the carboxymethyl ester of diclofenac. A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It has a role as an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a non-steroidal anti-inflammatory drug and a non-narcotic analgesic. It is a monocarboxylic acid, a carboxylic ester, a secondary amino compound, an amino acid and a dichlorobenzene. It derives from a diclofenac.
Trademarks
Airtal; Gerbin
Therapeutic Function
Analgesic, Antiinflammatory
Biochem/physiol Actions
Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.
Clinical Use
NSAID and analgesic
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists: antagonism of hypotensive effect; increased risk of nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more NSAIDs, including aspirin (increased side effects); avoid with ketorolac (increased risk of side effects and haemorrhage).
Antibacterials: possible increased risk of convulsions with quinolones.
Anticoagulants: effects of coumarins and phenindione enhanced; possibly increased risk of bleeding with heparins, dabigatran and edoxaban - avoid long term use with edoxaban.
Antidepressants: increased risk of bleeding with SSRIs and venlaflaxine.
Antidiabetic agents: effects of sulphonylureas enhanced.
Antiepileptics: possibly increased phenytoin concentration.
Antivirals: increased risk of haematological toxicity with zidovudine; concentration possibly increased by ritonavir.
Ciclosporin: may potentiate nephrotoxicity
Cytotoxics: reduced excretion of methotrexate; increased risk of bleeding with erlotinib.
Diuretics: increased risk of nephrotoxicity; antagonism of diuretic effect, hyperkalaemia with potassium-sparing diuretics.
Lithium: excretion decreased.
Pentoxifylline: increased risk of bleeding.
Tacrolimus: increased risk of nephrotoxicity.
Stoffwechsel
About two-thirds of a dose is excreted in the urine, mainly as hydroxymetabolites, the principal one being 4-hydroxyaceclofenac. A small amount is converted to diclofenac.

Aceclofenac Upstream-Materialien And Downstream Produkte

Aceclofenac Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

89796-99-6, Aceclofenac Verwandte Suche:

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