(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron

Bezeichnung:(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron

CAS-Nr480-18-2

Englisch Name:Taxifolin

CBNumberCB0402424

SummenformelC15H12O7

Molgewicht304.25

MOL-Datei480-18-2.mol

Synonyma

(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron

(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron physikalisch-chemischer Eigenschaften

Schmelzpunkt	230-233°C (dec.)
Siedepunkt	365.09°C (rough estimate)
Dichte	1.3326 (rough estimate)
Brechungsindex	1.4790 (estimate)
storage temp.	-20°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
pka	7.39±0.60(Predicted)
Farbe	White to Yellow
BRN	5299277
InChI	InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1
InChIKey	CXQWRCVTCMQVQX-LSDHHAIUSA-N
SMILES	[C@H]1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O
LogP	0.950
CAS Datenbank	480-18-2(CAS DataBase Reference)
EPA chemische Informationen	4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)- (480-18-2)

Sicherheit

R-Sätze:	22
S-Sätze:	22-24/25
WGK Germany	3
RTECS-Nr.	LK6920000
HazardClass	IRRITANT
HS Code	29329990

Gefahreninformationscode (GHS)

Taxifolin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Taxifolin, a chemical substance extracted from pine plants such as larch and Douglas fir. It belongs to the bioflavonoid pseudo-vitamin P, and its scientific name is dihydroquercetin. Japanese scholar Fukui first isolated it from the leaves of conifers (Chamaecyparis obtusa), and its biological activity was subsequently discovered and confirmed.
Chemische Eigenschaften
Yellow Solid
Verwenden
An antioxidant flavenoid.
Verwenden
(+)-Taxifolin is a flavanon compound which modulates chemopreventive genes.
Verwenden
Reference Standard in the analysis of herbal medicinal products
Application
Taxifolin is a flavonoid commonly found in onion, milk, French maritime pine bark and Douglas fir bark. It is also used in various commercial preparations like Legalon?, Pycnogenol?, and Venoruton?. This review focuses on taxifolin’s biological activities and related molecular mechanisms. It showed promising pharmacological activities in the management of inflammation, tumors, microbial infections, oxidative stress, cardiovascular, and liver disorders. The anti-cancer activity was more prominent than other activities evaluated using different in vitro and in vivo models. Further research on the pharmacokinetics, in-depth molecular mechanisms, and safety profile using well-designed randomized clinical studies are suggested to develop a drug for human use.
Definition
ChEBI: A taxifolin that has (2R,3R)-configuration.
Allgemeine Beschreibung
Taxifolin is a plant flavonoid, which may find applications in the treatment of coronary heart disease, angina pectoris, cerebral thrombosis, cerebral infarction and sequelae.

Taxifolin Upstream-Materialien And Downstream Produkte

(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

480-18-2, Taxifolin Verwandte Suche:

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