ARG-GLY-ASP

Bezeichnung:ARG-GLY-ASP

CAS-Nr99896-85-2

Englisch Name:ARG-GLY-ASP

CBNumberCB0364876

SummenformelC12H22N6O6

Molgewicht346.34

MOL-Datei99896-85-2.mol

ARG-GLY-ASP physikalisch-chemischer Eigenschaften

Schmelzpunkt	153-155℃ (ethyl ether )
Dichte	1.61±0.1 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	Soluble in 0.1N acetic acid at 20mg/ml
pka	2.85±0.10(Predicted)
Aggregatzustand	Powder
Wasserlöslichkeit	Soluble to 12 mg/mL (34.64 mM) in Water
InChIKey	IYMAXBFPHPZYIK-BQBZGAKWSA-N

Sicherheit

WGK Germany

Gefahreninformationscode (GHS)

ARG-GLY-ASP Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White to off-white powder
Verwenden
Arg-Gly-Asp has been used:
- to saturate the cell surface Arg-Gly-Asp (RGD) receptors and inhibit marrow stromal cell (MSC) attachment to peptide modified hydrogel
- in adhesion assay
- in inhibition assay to confirm the β1-integrin-dependency of cell adhesion
- in textile fabrication and RGD textile functionalization
- to engineer a population of human dermal fibroblasts with impaired migration
- to modify glass substrate and evaluate the behavior of human bone marrow mesenchymal stem cells (hBM-MSCs)
- in the cell culture of human mammary epithelial cells
Definition
ChEBI: Arg-Gly-Asp is an oligopeptide.
Allgemeine Beschreibung
Arg-Gly-Asp (RGD) is an integrin binding site, which belongs to the class of adhesive proteins. It functions as a brain tumor targeting ligand.
Biologische Aktivität
synthetic peptides containing the arginine-glycine-aspartate (rgd) were extensively used as inhibitors of integrin-ligand interactions in studies of cell adhesion, migration, growth and differentiation, since the rgd motif is an integrin-recognition motif found in many ligands.
Biochem/physiol Actions
Primary sequence involved with the binding of proteins to cell surfaces
in vitro
rgd peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. previous study demonstrates that rgd peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing [1].
in vivo
anima study suggested that the rgd-4c-fitc-peptide bound to both endothelial and tumor cells in vivo and that peptide targeting should allow the delivery of therapeutic drugs to both endothelial and tumor cells [2].
target
integrin-ligand interaction
Lager
Store at -20°C
Einzelnachweise
[1] nature. 1999 feb 11;397(6719):534-9.rgd peptides induce apoptosis by direct caspase-3 activation. buckley cd1, pilling d, henriquez nv, parsonage g, threlfall k, scheel-toellner d, simmons dl, akbar an, lord jm, salmon m.
[2] cancer res. 2002 sep 15;62(18):5139-43. arginine-glycine-aspartic acid (rgd)-peptide binds to both tumor and tumor-endothelial cells in vivo. zitzmann s1, ehemann v, schwab m.

ARG-GLY-ASP Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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