6-Chlor-o-toluidin

Bezeichnung:6-Chlor-o-toluidin

CAS-Nr87-63-8

Englisch Name:2-Chloro-6-methylaniline

CBNumberCB0361613

SummenformelC7H8ClN

Molgewicht141.6

MOL-Datei87-63-8.mol

Synonyma

6-Chlor-o-toluidin

6-Chlor-o-toluidin physikalisch-chemischer Eigenschaften

Schmelzpunkt	10-12 °C(lit.)
Siedepunkt	215 °C(lit.)
Dichte	1.152 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.576(lit.)
Flammpunkt	210 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Chloroform (Slightly), Ethyl Acetate (Slightly)
Aggregatzustand	Oil
pka	2.51±0.10(Predicted)
Farbe	Clear Colourless to Pale Purple
Wasserlöslichkeit	Immiscible
BRN	774624
InChIKey	WFNLHDJJZSJARK-UHFFFAOYSA-N
CAS Datenbank	87-63-8(CAS DataBase Reference)
NIST chemische Informationen	Benzenamine, 2-chloro-6-methyl-(87-63-8)
EPA chemische Informationen	6-Chloro-2-methylaniline (87-63-8)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-20/21/22
S-Sätze:	26-36-36/37/39
RIDADR	UN 3429 6.1/PG 3
WGK Germany	3
RTECS-Nr.	XU5100000
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29214300

Gefahreninformationscode (GHS)

2-Chloro-6-methylaniline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
2-chloro-6-methylaniline is an important organic synthesis intermediate widely applied to chemical pharmacy, pesticides, and organic synthesis. In the aspects of chemical pharmacy and pesticides, 2-chloro-6-methylaniline can be used as a reaction starting material to participate in the preparation processes of tyrosine kinase inhibitors dasatinib, indazole derivatives with anti-breast cancer activity, 2-methyl-6-chlorophenyl sulfonylurea derivatives with bacteriostatic activity and the like; in the aspect of organic synthesis, 2-chloro-6-methylaniline can introduce chemical groups such as hydrazine, nitro, cyano, halogen (F, Cl, Br), and the like into an aromatic ring through diazotization reaction, thereby participating in wide chemical reactions.
Chemische Eigenschaften
clear yellow to red-brown liquid
Chemische Eigenschaften
The chloromethylanilines are colorless or white crystalline solids or liquids, some have a mild fishy odor.
Verwenden
2-Chloro-6-methylaniline is a substituted aniline used in the preparation of various pharmaceutical compounds. 2-Chloro-6-methylaniline showed inhibition of the polymerization of vinyl acetate.
synthetische
A preparation method of 2-chloro-6-methylaniline takes 3-chloro-5-methyl-4-nitroaniline as a starting material, water as a solvent, and sulfuric acid as a reactant. Eliminates amino groups through diazotization reaction, reduces by hypophosphorous acid to obtain an intermediate, and finally takes iron powder as reducing nitro groups to prepare the 2-chloro-6-methylaniline through a one-pot reaction.
mögliche Exposition
Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill birds. It is marketed as pelleted bait for control of bird populations.
Versand/Shipping
UN2239 Chlorotoluidines, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3429 Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1- Poisonous materials
Inkompatibilitäten
Incompatible with oxidizers, strong acids; chloroformates, and acid anhydrides, isocyanates, aldehydes forming fire and explosive hazards.

2-Chloro-6-methylaniline Upstream-Materialien And Downstream Produkte

6-Chlor-o-toluidin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

87-63-8, 2-Chloro-6-methylaniline Verwandte Suche:

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