CARBOXY-PTIO Struktur

CARBOXY-PTIO

Bezeichnung:CARBOXY-PTIO

CAS-Nr148819-94-7

Englisch Name:CARBOXY-PTIO

CBNumberCB0359762

SummenformelC14H16KN2O4*

Molgewicht315.39

MOL-Datei148819-94-7.mol

CARBOXY-PTIO physikalisch-chemischer Eigenschaften

Schmelzpunkt	141-143°C
storage temp.	2-8°C
Löslichkeit	H₂O: >20 mg/mL
Aggregatzustand	solid
Farbe	blue
Wasserlöslichkeit	Soluble in water. Also soluble in ethanol, methanol, DMSO or DMF.
Stabilität	Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
CAS Datenbank	148819-94-7(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
WGK Germany	3
HS Code	2918999090

CARBOXY-PTIO Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
A nitric oxide (NO) scavenger.? Carboxy-PTIO (148819-94-7) reacts with NO with 1:1 stoichiometry1 producing NO2–/NO3–.?? In LPS-induced endotoxin shock, carboxy-PTIO reversed hypotension and renal dysfunction and increased survival in a rat model.2 A very useful tool for probing the involvement of NO in physiological processes.3,4
Chemische Eigenschaften
blue powder
Verwenden
Carboxy-PTIO potassium salt has been used to check the generation of hydroxyl radicals or nitric in reaction mixtures to examine the generation of nitric oxide in reaction mixture. It has also been added to neurons to analyse its effect on glucose/oxygen/serum deprivation (GOSD) condition(4)
Verwenden
A water soluble, stable organic free radical that reacts stoichiometrically with NO. Carboxy-PTIO converts NO to NO2 and does not dramatically affect other NO related metabolites. This scavenger allows for the specific investigation of the effect of NO.
Verwenden
Carboxy-PTIO is a NO scavenger. It reacts stoichiometrically with NO and can be used for EPR detection of NO.
Definition
ChEBI: Potassium 2-(4-carboxylatophenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide is a potassium salt having 2-(4-carboxylatophenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide as the counterion. It has a role as a radical scavenger and an apoptosis inhibitor. It is a potassium salt and an organic radical. It contains a carboxylato-PTIO.
Allgemeine Beschreibung
2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide?(carboxy-PTIO) is mainly considered as a scavenger of nitric oxide?(NO).
Biologische Aktivität
A stable, water-soluble free radical that reacts stoichiometrically with NO. Almost twice as strong an inhibitor as N( ω )-nitroarginine or N-methylarginine.
Biochem/physiol Actions
Carboxy-PTIO can make a quick reaction with nitric oxide?(NO) to produce nitrogen dioxide (NO2). It can be used to prevent hypotension and endotoxic shock, stimulated by lipopolysaccharide in- vivo. Carboxy-PTIO can also block in vitro vascular relaxation, stimulated by NO.
Lager
+4°C
Einzelnachweise
Akaike et al. (1993), Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction, Biochemistry, 32 827 Yoshida et al. (1994), Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity; Biochem. Biophys. Res. Commun., 202 923 Hada et al. (2019), Nitric Oxide Is Involved in Heavy Ion-Induced Non-Targeted Effects in Human Fibroblasts; Int. J. Mol. Sci., 20 4327 Jin et al. (2020), A novel quinolinylmethyl substituted ethylenediamine compound exerts anti-cancer effects via stimulating the accumulation of reactive oxygen species and NO in hepatocellular carcinoma cells; Eur. J. Pharmacol., 885 173497

CARBOXY-PTIO Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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