3-Aminophenylborsaeure hemisulfat

Bezeichnung:3-Aminophenylborsaeure hemisulfat

CAS-Nr66472-86-4

Englisch Name:3-Aminobenzeneboronic acid hemisulfate salt

CBNumberCB0357728

SummenformelC12H18B2N2O8S

Molgewicht371.96692

MOL-Datei66472-86-4.mol

Synonyma

3-Aminophenylborsaeure hemisulfat

3-Aminophenylborsaeure hemisulfat physikalisch-chemischer Eigenschaften

Schmelzpunkt	≥300 °C
storage temp.	Inert atmosphere,2-8°C
Wasserlöslichkeit	Soluble in water
Aggregatzustand	Crystalline Powder
Farbe	White to slightly beige
Sensitive	Hygroscopic
BRN	8094151
InChIKey	XMVGYYBQCXVVHU-UHFFFAOYSA-N
CAS Datenbank	66472-86-4

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
F	3-10
HazardClass	IRRITANT
HS Code	29310095

Gefahreninformationscode (GHS)

3-Aminobenzeneboronic acid hemisulfate salt Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
White to slightly beige crystalline powder
Verwenden
3-Aminobenzeneboronic acid hemisulfate salt is a boronic acid derivative, which can be used as an intermediate in pharmaceutical synthesis. Adsorbent additive for the chromatographic separation of 3'-terminal polynucleotides from RNA.
Application
3-Aminophenylboronic acid hemisulfate salt is used in the synthesis of:
Phenylboronic acid-functionalized inverse opal hydrogels within microfluidic flow cells for glucose sensing.
Phenylboronic acid-salicylhydroxamic acid-derived complexing reagent for protein immobilization on chromatographic support.
It can also be used in the preparation of phenylboronic acid (PBA) monolayer-modified Au electrode for the voltammetric sensing of uridine and cytidine.
synthetische
3-Aminobenzeneboronic acid hemisulfate salt synthesis: Benzenamine, 3-bromo-N-(diphenylmethylene)- (80,0 g; 0.24 moles) was added to the cryogenic reactor along with 1.4 equivalents of triisopropyl borate and dissolved in tetrahydrofuran. The resulting solution was cooled to -80°C under an inert atmosphere and 1.35 equivalents of n-butyllithium (as a solution in n-hexane) was added maintaining the internal temperature. When complete conversion was achieved, the reaction mixture was added to a dilute mixture of sulfuric acid (1 M) and toluene. The layers were separated to obtain an aqueous solution of 3-aminophenylboronic acid hydrogen sulfate (assay yield: 85%). 3-Aminobenzeneboronic acid hemisulfate salt can be obtained by precipitating a 0.5 M aqueous solution at pH 7.2 (pH corrected with 33% aqueous NaOH) at a temperature of 0-5°C. Filtration and drying under vacuum at 40°C for 8 hours yielded 21.7 g of 3-Aminobenzeneboronic acid hemisulfate salt (0.16 moles; 66% molar yield).

3-Aminobenzeneboronic acid hemisulfate salt Upstream-Materialien And Downstream Produkte

3-Aminophenylborsaeure hemisulfat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

66472-86-4, 3-Aminobenzeneboronic acid hemisulfate salt Verwandte Suche:

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