N-Boc-PEG4-bromide

N-Boc-PEG4-bromide Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  N-Boc-PEG4-bromide is a PEG linker containing a bromide group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

• Biologische Aktivität

  N-Boc-PEG5-bromide is a PROTAC linker that belongs to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

• in vitro

  PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

• target

  Cleavable

  PEGs

  Alkyl/ether

N-Boc-PEG4-bromide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(51)Suppliers

1392499-32-9, N-Boc-PEG4-bromide Verwandte Suche: