CGP4540
Bezeichnung:CGP4540
CAS-Nr100990-46-3
Englisch Name:CGP4540
CBNumberCB03345438
Molgewicht0
MOL-DateiMol file
CGP4540 Chemische Eigenschaften,Einsatz,Produktion Methoden
-
Definition
ChEBI: Amoscanate is an isothiocyanate that is phenyl isothiocyanate in which the hydrogen at the para- position has been replaced by a 4-nitroanilinyl group. It has a role as a schistosomicide drug. It is a C-nitro compound, an isothiocyanate and a secondary amino compound. It is functionally related to a diphenylamine. -
Biologische Aktivität
Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma[1]. Amoscanate (500 mg/kg; p.o.; 10 days) destructs ependyma and periventricular brain[1].Amoscanate (250 and 500 mg/kg; p.o.; 28 days) elicits necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum[1].Amoscanate (25~500 mg/kg; p.o.; 20 days) elicits progressive necrosis of ependyma[1].Amoscanate elicits massive ultrastructural damage in ependymal cells[1]. -
Einzelnachweise
[1]. Johanson C, et al. The distributional nexus of choroid plexus to cerebrospinal fluid, ependyma and brain: toxicologic/pathologic phenomena, periventricular destabilization, and lesion spread. Toxicol Pathol. 2011;39(1):186-212.
CGP4540 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global(10)Suppliers
-
Telefon +undefined-21-51877795
E-Mail ivan@atkchemical.com
-
Telefon +1-708-310-1919<br/>+1-13798911105
E-Mail sales@invivochem.cn
-
Amadis Chemical Company Limited
Telefon 571-89925085
E-Mail sales@amadischem.com
-
Shanghai JiYi Biotechnology Co. Ltd.
Telefon 13621943973
E-Mail sales@shjiyipharmatech.com
-
Shanghai Chaolan Chemical Technology Center
Telefon QQ:65489617<br/>15618227136
E-Mail info@SuperLan-chem.com
-
Medi-tech Bioscientific Co., Ltd.
Telefon 0519-83246372 13585352506
E-Mail
-
Nanjing KaiMubo Pharmaceutical Co., Ltd.
Telefon 025-66162170
E-Mail
-
Telefon 021-58447131<br/>13564518121
E-Mail sales@dcchemicals.com
-
Beijing Jin Ming Biotechnology Co., Ltd.
Telefon 010-60605840<br/>15801484223;
E-Mail psaitong@jm-bio.com
-
Telefon 13549236410
E-Mail sales@invivochem.cn
1of2