N-ACETYLTRYPTAMINE Struktur

N-ACETYLTRYPTAMINE

Bezeichnung:N-ACETYLTRYPTAMINE

CAS-Nr1016-47-3

Englisch Name:N-ACETYLTRYPTAMINE

CBNumberCB0329617

SummenformelC12H14N2O

Molgewicht202.25

MOL-Datei1016-47-3.mol

N-ACETYLTRYPTAMINE physikalisch-chemischer Eigenschaften

Schmelzpunkt	74.0 to 78.0 °C
Siedepunkt	200°C/0.2mmHg(lit.)
Dichte	1.164±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	alcohol: soluble
Aggregatzustand	powder
pka	16.48±0.46(Predicted)
Farbe	White to Light yellow to Light orange
maximale Wellenlänge (λmax)	290nm(MeOH)(lit.)
CAS Datenbank	1016-47-3

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
HS Code	2933.99.8290

Gefahreninformationscode (GHS)

N-ACETYLTRYPTAMINE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
The Argentinian medicinal plant Prosopsis nigra contains this alkaloid of the simple indole type which has recently been isolated and characterized. It may be a direct precursor in the biosynthesis of the {:l-carboline bases.
Beschreibung
N-acetyl Tryptamine is a structural analog of melatonin (5-methoxy-N-acetyltryptamine; ) that binds the melatonin MT₂ receptor (K_i = 41 nM). It acts as a melatonin receptor antagonist in frog skin and chicken retina and as a partial agonist in rabbit retina. N-acetyl Tryptamine is also a reaction product of assays for serotonin N-acetyltransferase, the penultimate enzyme in the melatonin biosynthetic pathway.
Verwenden
N-acetyl Tryptamine is a structural analog of melatonin (5-methoxy-N-acetyltryptamine; ) that binds the melatonin MT2 receptor (Ki = 41 nM). It acts as a melatonin receptor antagonist in frog skin and chicken retina and as a partial agonist in rabbit retina. N-acetyl Tryptamine is also a reaction product of assays for serotonin N-acetyltransferase, the penultimate enzyme in the melatonin biosynthetic pathway.
Definition
ChEBI: A tryptamine compound having an acetyl substituent attached to the side-chain amino function.
Enzyminhibitor
This partial receptor agonist (FW = 202.26 g/mol; CAS 1016-47-3; Soluble to 100 mM in DMSO) is a melatonin (or 5-methoxy-N-acetyltryptamine) mimic and is more potent than melatonin in inhibiting dopamine release fom presynaptic melatonin receptor site of rabbit retina labeled in vitro with [3H]dopamine.
Lager
Room temperature
Einzelnachweise
Moro, Graziano, Coussio, Phytochern., 14,827 (1975)

N-ACETYLTRYPTAMINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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