1627710-50-2 Struktur

1627710-50-2

Bezeichnung:1627710-50-2

CAS-Nr1627710-50-2

Englisch Name:1627710-50-2

CBNumberCB03060937

SummenformelC22H21F2N3O

Molgewicht381.42

MOL-Datei1627710-50-2.mol

1627710-50-2 physikalisch-chemischer Eigenschaften

Siedepunkt	481.1±45.0 °C(Predicted)
Dichte	1.257±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
Löslichkeit	Soluble in DMSO
Aggregatzustand	crystalline solid
pka	5.86±0.25(Predicted)
Farbe	White to off-white

Sicherheit

HS Code

2933998090

Gefahreninformationscode (GHS)

1627710-50-2 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
LJH685 is a selective and potent RSK inhibitor (1). The p90 ribosomal S6 kinase (RSK) family of serine/threonine kinases is linked to various cancers and its substrate phosphorylation is also related to the regulation of cell survival, proliferation, and cell polarity (2).
Biologische Aktivität
ljh685 is a rsk (p90 ribosomal s6 kinase) inhibitor.the p90 ribosomal s6 kinase (rsk) family of serine/threonine kinases is found to be expressed in a variety of cancers and its substrate phosphorylation has been implicated in direct regulation of cell proliferation, cell survival, as well as cell polarity.
in vitro
in a previous study, the structural analysis results confirmed the binding of ljh685 to the rsk2 n-terminal kinase atp-binding site, which suggested that the inhibitor ljh685 adopted an unusual nonplanar conformation that explained its excellent selectivity for rsk family kinases. in addition, ljh685 and it analog lji308 could efficiently inhibit rsk activity in vitro and in cells. moreover, in a subset of examined cell lines, the cellular inhibition of rsk and its phosphorylation of yb1 on ser102 were found to be closely associate with the inhibition of cell growth in an anchorage-independent growth setting [1].
IC 50
6 nm, 5 nm and 4 nm for the biochemical activities of rsk1, rsk2, and rsk3, respectively
Einzelnachweise
[1] aronchik i, appleton ba,basham se,crawford k,del rosario m,doyle lv,estacio wf,lan j,lindvall mk,luu ca,ornelas e,venetsanakos e,shafer cm,jefferson ab. novel potent and selective inhibitors of p90 ribosomal s6 kinase reveal the heterogeneity of rsk function in mapk-driven cancers. mol cancer res.2014 may;12(5):803-12.

1627710-50-2 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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