3-Propanolid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H330：Lebensgefahr bei Einatmen.

  H350：Kann Krebs verursachen.

• Sicherheit

  P202：Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2-Oxetanone Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE FLüSSIGKEIT MIT STECHENDEM GERUCH.

• CHEMISCHE GEFAHREN

  Kann beim Erwärmen polymerisieren. Feuer- und Explosionsgefahr.

• ARBEITSPLATZGRENZWERTE

  TLV: 0,5 ppm (als TWA); Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
  MAK: Hautresorption; Krebserzeugend Kategorie 2; (DFG 2006).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation und durch Verschlucken.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz verätzt die Augen und reizt die Haut und die Atemwege.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Wahrscheinlich krebserzeugend für den Menschen.

• LECKAGE

  Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Persönliche Schutzausrüstung: Vollschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.

• R-Sätze Betriebsanweisung:

  R45:Kann Krebs erzeugen.
  R26:Sehr giftig beim Einatmen.
  R36/38:Reizt die Augen und die Haut.

• S-Sätze Betriebsanweisung:

  S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

• Aussehen Eigenschaften

  C3H4O2. (1,3-Propiolacton, ß-Propiolacton). Flüssigkeit.

• Gefahren für Mensch und Umwelt

  Dämpfe sind sehr giftig beim Einatmen. Reizt die Augen und die Haut; kann zu Blasenbildung und Hornhauttrübung führen.
  Ist vermutlich fruchtschädigend.
  Kann Krebs erzeugen.

• Schutzmaßnahmen und Verhaltensregeln

  Nur im Abzug arbeiten.
  Schutzhandschuhe (nur als kurzzeitiger Spritzschutz).

• Verhalten im Gefahrfall

  Verschüttete Substanz oder Lösung mit Absorptionsmaterial (z.B. Rench-Rapid oder Vermiculite) aufnehmen und als Sondermüll entsorgen. Bei größeren Mengen Labor räumen und umgebungsluftunabhängigen Atemschutz tragen.
  CO₂, Pulverlöscher, oder Wasser im Sprühstrahl.

• Erste Hilfe

  Nach Hautkontakt: Mit Seife und viel Wasser abwaschen.
  Nach Augenkontakt: Mindestens 15 Minuten mit geöffnetem Lidspalt mit Wasser spülen. Augenarzt!
  Nach Einatmen: Frischluft. Arzt!
  Nach Verschlucken: Wiederholt reichlich Wasser mit Aktivkohle-Zusatz trinken lassen. Arzt!
  Nach Kleidungskontakt: Benetzte Kleidung entfernen und mit viel Wasser abwaschen.
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Kleinmengen als Sondermüll (halogenfreie Lösemittel) entsorgen.

• Beschreibung

  Beta-propiolactone is a colorless liquid with a strong, slightly sweet odor. It may occur naturally, but no clear documentation of its occurrence in nature was found, and it must be synthesized for commercial purposes. Beta-propiolactone is unstable at room temperature but stable when stored at 5 ℃ in glass containers.
  Its tendency to be unstable and react with other molecules in the vicinity is responsible for both its toxicity and its usefulness. Significant commercial production of beta-propiolactone took place during the late 1950s through the mid-1970s, when it was widely used in chemical synthesis in reactions with other molecules to produce new chemicals. All lactones are characterized by a ring structure consisting of two or more carbon atoms – as can be seen from its structure, beta-propiolactone has three in its ring – and a single oxygen, coupled with an adjacent ketone. The fewer the carbons in the ring, the more ‘strained’ is the ring structure and the more unstable and reactive its characteristics. When the ring bonds break, the betapropiolactone molecules attach to other nearby molecules.

• Chemische Eigenschaften

  β-Propiolactone is a colorless liquid which slowly hydrolyzes to hydracrylic acid and must be cooled to remain stable. It reacts with alcohols, acid chlorides, ammonia, and water to yield β-substituted propionic acid derivatives. The most important characteristic of the substance is its ability to polymerize. This highly exothermic process occurs simply by warming, although it is also catalyzed by both acid and base.

• Physikalische Eigenschaften

  β-Propiolactone is a colorless, highly reactive liquid,thatis solublein water, alcohol, acetone, and chloroform (solubilityinwaterat 25℃, 37 vol %).

• Verwenden

  As late as 1974, b-propiolactone was used in the United States in the preparation of acrylic acid and acrylate esters. Today, its principal significance is as a reactive intermediate in organic syntheses; a small amount is treated with ammonia to provide balanine. b-Propiolactone was also used as a disinfectant. It appeared to be an attractive replacement for formaldehyde due to its 25-fold greater disinfecting power, but it has since been abandoned because of its carcinogenic properties.

• Verwenden

  Versatile intermediate in organic synthesis.

• Verwenden

  Reacts with bacteriphage DNA causing inactivation, repair and recombination

• Definition

  ChEBI: Beta-propiolactone is a propan-3-olide. It is functionally related to a 3-hydroxypropionic acid. It derives from a hydride of an oxetane.

• synthetische

  β-Propiolactone is synthesized by passing equimolar amounts of ketene and formaldehyde into either acetone or b-propiolactone itself. The reaction is carried out at low temperature (<20℃) with a yield of ca. 90 %. Both aluminum chloride and zinc chloride have been employed as catalysts, and the use of methyl borate has also been suggested.

• Trademarks

  Betaprone (Forest).

• Allgemeine Beschreibung

  A colorless liquid with a slightly sweetish, pungent odor. Used as an intermediate in organic synthesis; disinfectant, sterilant for blood plasma, tissue grafts, vaccines, enzymes and surgical instruments.

• Air & Water Reaktionen

  Slow reaction with water to form beta- hydroxypropionic acid.

• Reaktivität anzeigen

  2-Oxetanone is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. 2-Oxetanone may be incompatible with alkalis.

• Hazard

  Strong skin and upper respiratory tract irri- tant, skin cancer. Possible carcinogen. Worker expo- sure should be minimized.

• Health Hazard

  The toxicity potential of 2-Oxetanone via inhalation or ingestion is high; may cause death or permanent injury after very short exposures to small quantities. It is a carcinogen.

• Brandgefahr

  Containers may explode. When heated to decomposition, 2-Oxetanone emits acrid smoke and fumes. Stable when stored at 41F. Avoid storing in areas of exposure to the direct rays of the sun and in areas of high fire hazard. Tends to polymerize on storage. Avoid elevated temperatures.

• Sicherheitsprofil

  Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by inhalation. Moderately toxic by intraperitoneal route. An initiator. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

• mögliche Exposition

  β-Propiolactone is used as a chemical intermediate in synthesis of acrylic acid and esters, acrylate plastics; as a vapor sterilizing agent; phase disinfectant; and a viricidal agent.

• Carcinogenicity

  β-Propiolactone is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.

• Environmental Fate

  Chemical/Physical. Slowly hydrolyzes to hydracrylic acid (Windholz et al., 1983). In a reactor heated to 250 °C and a pressure of 12 mmHg, β-propiolactone decomposed to give equal amounts of ethylene and carbon dioxide (James and Wellington, 1969).

• Versand/Shipping

  UN3382 Toxic by inhalation liquid, n.o.s. with an LC 50 ≤1000 mL/m 3 and saturated vapor concentration ≥10 LC 50 , Hazard class: 6.1; Labels: 6.1 Technical Name Required, Inhalation Hazard Zone B. UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

• läuterung methode

  Fractionally distil the lactone from sodium under reduced pressure. It gives an acidic solution in H2O. It irritates the skin and is a possib

• Toxicity evaluation

  It is soluble in water (370 g l1 at 25°C) and miscible in other common organic solvents including acetone, chloroform, diethyl ether, and ethanol (Log Kow 0.462). Hydrolysis occurs in water where the half-life in aqueous media at 25°C is approximately 3.5 h. If released to soil, relatively rapid hydrolysis can be expected to occur in the presence of moisture. Significant evaporation may occur from dry surfaces. With a vapor pressure of 3.4 mm Hg at 25°C, it can also vaporize into the air as temperature rises. If released to the atmosphere, beta-propiolactone is expected to exist in the gas phase, where it may be relatively more persistent in the absence of moisture than it is in aqueous media. The half-life for the reaction with photochemically produced hydroxyl radicals was estimated to be a relatively slow rate of 45 days in the atmosphere.

• Inkompatibilitäten

  Reacts with water, causing decomposi- tion and forming 3-hydroxypropionic acid (CAS: 503-66- 3), an irritant. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Incompatible with acet- ates, halogens, thiocyanates, thiosulfates, strong oxidizers; strong bases. Forms explosive mixture with air above 75℃. May polymerize upon storage or due to warming. Stable if kept under refrigeration @ 5 to 10 ℃/40 to 50 ℃.

• Waste disposal

  Dissolve or mix the material with a combustible solvent and burn in a chemical incinera- tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

2-Oxetanone Upstream-Materialien And Downstream Produkte

3-Propanolid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(180)Suppliers

57-57-8, 2-Oxetanone Verwandte Suche: