3-(p-Chlorphenyl)-DL-alanin

Bezeichnung:3-(p-Chlorphenyl)-DL-alanin

CAS-Nr7424-00-2

Englisch Name:DL-4-Chlorophenylalanine

CBNumberCB0261841

SummenformelC9H10ClNO2

Molgewicht199.63

MOL-Datei7424-00-2.mol

Synonyma

3-(p-Chlorphenyl)-DL-alanin

3-(p-Chlorphenyl)-DL-alanin physikalisch-chemischer Eigenschaften

Schmelzpunkt	>240 °C (dec.)(lit.)
Siedepunkt	339.5±32.0 °C(Predicted)
Dichte	1.2409 (rough estimate)
Brechungsindex	1.5790 (estimate)
storage temp.	room temp
Löslichkeit	Aqueous Acid (Slightly), Methanol (Slightly)
Aggregatzustand	Powder
pka	pK1: 2.08(+1);pK2: 8.96(0) (25°C)
Farbe	White to almost white
Wasserlöslichkeit	slightly soluble
BRN	2805758
CAS Datenbank	7424-00-2(CAS DataBase Reference)
EPA chemische Informationen	4-Chlorophenylalanine (7424-00-2)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25-43
S-Sätze:	36/37-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	AY4390010
TSCA	Yes
HS Code	29224985
Giftige Stoffe Daten	7424-00-2(Hazardous Substances Data)

Gefahreninformationscode (GHS)

DL-4-Chlorophenylalanine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Crystalline
Verwenden
4-Chloro-DL-phenylalanine has been used:
- as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras⁺ male zebrafish
- to induce insomnia in rat models
- used to treat embryos to examine its effect on serotonin
- for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
- to feed flies to explore serotonin effect
Verwenden
An irreversible tryptophan hydroxylase inhibitor.
Verwenden
4-Chloro-DL-phenylalanine is an irreversible tryptophan hydroxylase inhibitor that depletes serotonin in the brain.
Definition
ChEBI: 2-amino-3-(4-chlorophenyl)propanoic acid is a phenylalanine derivative.
Biologische Aktivität
4-Chloro-DL-phenylalanine (Fenclonine, PCPA, CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin.
Biochem/physiol Actions
4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.
Sicherheitsprofil
An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx and Cl-.
in vivo
4-Chloro-DL-phenylalanine(PCPA) markedly attenuates MCT(monocrotaline)-induced pulmonary vascular remodeling and lung inflammation, inhibits the expression of Tph-1 and SERT and suppresses the expression of MMP-2/-9, TIMP-1/-2, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1). PCPA inhibits 5-HT by suppressing Tph-1, regulating SERT and the serotonin downstream signaling pathway.
Lager
Room temperature

DL-4-Chlorophenylalanine Upstream-Materialien And Downstream Produkte

3-(p-Chlorphenyl)-DL-alanin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

7424-00-2, DL-4-Chlorophenylalanine Verwandte Suche:

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