TPPU Struktur

TPPU

Bezeichnung:TPPU

CAS-Nr1222780-33-7

Englisch Name:TPPU

CBNumberCB02592718

SummenformelC16H20F3N3O3

Molgewicht359.34

MOL-Datei1222780-33-7.mol

TPPU physikalisch-chemischer Eigenschaften

Schmelzpunkt	195-196 °C
Siedepunkt	448.9±45.0 °C(Predicted)
Dichte	1.31±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: soluble10mg/mL, clear (warmed)
Aggregatzustand	powder
pka	13.11±0.20(Predicted)
Farbe	white to beige

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25
S-Sätze:	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3

Gefahreninformationscode (GHS)

TPPU Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
TPPU is an epoxide hydrolase inhibitor, which has potential in the reduction of inflammatory pain.
Verwenden
Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects. TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively). The pharmacokinetics of this compound are dramatically superior to those of the 1-adamantylurea based inhibitors, like AUDA.[Cayman Chemical]
Verwenden
TPPU has been used as a soluble epoxide hydrolase (SEH) inhibitor to characterize its pharmacokinetic (PK) and pharmacodynamic properties in rodents. It has also been used as a SEH inhibitor to study its effects on 12,13-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME) concentrations in nervous tissues.
Biologische Aktivität
tppu is a potent inhibitor of both human and mouse seh.the soluble epoxide hydrolase (seh) can convert epoxides to the corresponding diols by the catalytic addition of a water molecule. seh is implicated in various disease states for its ability to metabolize fatty acid epoxides such as epoxyeicosatrienoic acids and leukotoxin, important endogenous signaling lipids, to less active dihydroxyeicosatrienoic acids and toxic, proinflammatory leukotoxin diols, respectively. seh inhibitors are of growing interest for therapeutic use since they have been shown to increase the in vivo concentration of eets and other fatty acid epoxides.
Biochem/physiol Actions
TPPU is a potent sEH inhibitor (IC50 = 3.7 nM) that has been shown to have very favorable PK attributes in cynomolgus monkeys. sEH converts epoxyeicosatrienoic acids (EETs) to dihydroxyiecosatrienoic acids (DHETs), and sEH inhibitors display anti-inflammatory and anti-atherosclerotic effects.
in vitro
tppu was identified as a potent inhibitor of both human and mouse seh with ic50 of 3.7 and 2.8 nm, respectively [1].
in vivo
animal study found that oral administration of 13 1-aryl-3-(1-acylpiperidin-4-yl)urea inhibitors including tppu in mice showed substantial improvements in pharmacokinetic parameters over previously reported 1-adamantylurea based inhibitors. for example, 1-(1-(cyclopropanecarbonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea, a close analog of tppu, had a 7-fold increase in potency, a 65-fold increase in cmax, and a 3300-fold increase in auc over its adamantine analogue 1-(1-adamantyl)-3-(1-propionylpiperidin-4-yl)urea. this seh inhibitor displayed a 1000-fold increase in potency when compared to morphine by reducing hyperalgesia using the in vivo carrageenan induced inflammatory pain model [1].
IC 50
human and mouse seh (ic50 = 3.7 and 2.8 nm, respectively)
Einzelnachweise
[1] rose, t. e.,morisseau, c.,liu, j.y., et al. 1-aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. j med chem. 2010 oct 14;53(19):7067-75.

TPPU Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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