N-Ethyl-2-(isopropyl)-5-methylcyclohexancarboxamid

Bezeichnung:N-Ethyl-2-(isopropyl)-5-methylcyclohexancarboxamid

CAS-Nr39711-79-0

Englisch Name:N-Ethyl-p-menthane-3-carboxamide

CBNumberCB0252522

SummenformelC13H25NO

Molgewicht211.34

MOL-Datei39711-79-0.mol

Synonyma

N-Ethyl-2-(isopropyl)-5-methylcyclohexancarboxamid

N-Ethyl-2-(isopropyl)-5-methylcyclohexancarboxamid physikalisch-chemischer Eigenschaften

Schmelzpunkt	87-102 °C
alpha	D -49 to -54°
Siedepunkt	351.04°C (rough estimate)
Dichte	0.9305 (rough estimate)
Dampfdruck	0.007Pa at 25℃
Brechungsindex	1.4410 (estimate)
FEMA	3455 \| N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO: ≥ 100 mg/mL (473.17 mM); Water: < 0.1 mg/mL (insoluble)
pka	16.27±0.60(Predicted)
Aggregatzustand	powder to crystal
Farbe	White to Almost white
Geruch (Odor)	at 25.00 % in dipropylene glycol. mild mentholic minty
Geruchsart	minty
Biologische Quelle	synthetic
Wasserlöslichkeit	insoluble
Merck	14,3825
JECFA Number	1601
InChIKey	VUNOFAIHSALQQH-UHFFFAOYSA-N
LogP	2.902 at 25℃
CAS Datenbank	39711-79-0(CAS DataBase Reference)
EPA chemische Informationen	Cyclohexanecarboxamide, N-ethyl-5-methyl-2-(1-methylethyl)- (39711-79-0)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36-41-22
S-Sätze:	39-26
WGK Germany	2
HS Code	29242990
Toxizität	LD50 in mice, rats (g/kg): 5.3, 2.9 orally (Parrish)

Gefahreninformationscode (GHS)

N-Ethyl-p-menthane-3-carboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
R41:Gefahr ernster Augenschäden.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S39:Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Slight menthol-like cooling effect aroma
Chemische Eigenschaften
white crystalline powder
Chemische Eigenschaften
N-ethyl-p-menthane-3-carboxamide is an odorless white, crystalline solid. The compound has a strong and clear physiological cooling effect and is used mainly in oral care products.
Verwenden
WS 3 is a selective transient receptor potential melastatin-8 ligand.
Verwenden
Physiological coolant in foods, beverages, toiletries, cosmetics and pharmaceuticals.
Definition
ChEBI: Ethyl menthane carboxamide is a p-menthane monoterpenoid.
Aroma threshold values
Aroma characteristics at 1.0%. Virtually odorless
Taste threshold values
Taste characteristics at 10 to 100 ppm. Intense lingering cooling. The cooling sensation builds slow but steadily and grows to a lingering cooling mouthfeel with a slightly camphoraceous and minty character.
Flammability and Explosibility
Not classified
Handelsname
Winsense WS-3 (Renessenz)
Biologische Aktivität
Cooling agent that is an agonist at TRPM8 receptors (EC 50 = 3.7 μ M).
Synthese
0.89 g (0.0091 mol) of polyphosphoric acid (85%) and 0.42 g (0.0091 mol) of ethanol were weighed. 0.54 g (0.0046 mol) of diethylcarbonate was added dropwise slowly while cooling in an ice bath, wherein the temperature increases slightly. After about 5 minutes, 0.5 g (0.0030 mol) of p-menthane-3-carbonitrile was added. The reaction solution was heated and stirred for 102 hours at 150??C. At the end of the reaction by GC, about 70% of desired N-Ethyl-p-menthane-3-carboxamide was formed.Fig The synthetic method 1 of N-Ethyl-p-menthane-3-carboxamide

N-Ethyl-2-(isopropyl)-5-methylcyclohexancarboxamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

39711-79-0, N-Ethyl-p-menthane-3-carboxamide Verwandte Suche:

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