2-Desoxy-D-glucose

Bezeichnung:2-Desoxy-D-glucose

CAS-Nr154-17-6

Englisch Name:2-Deoxy-D-glucose

CBNumberCB0251338

SummenformelC6H12O5

Molgewicht164.16

MOL-Datei154-17-6.mol

Synonyma

2-Desoxy-D-glucose

2-Desoxy-D-glucose physikalisch-chemischer Eigenschaften

Schmelzpunkt	146-147 °C(lit.)
alpha	45.5 º (c=2, H2O)
Siedepunkt	211.61°C (rough estimate)
Dichte	1.1738 (rough estimate)
Brechungsindex	46.5 ° (C=1, H2O)
storage temp.	2-8°C
Löslichkeit	H₂O: 50 mg/mL, clear, colorless to faintly yellow
Aggregatzustand	crystalline
pka	pK1:12.52 (25°C)
Farbe	white
Optische Aktivität	+38.5 → +45.9
Wasserlöslichkeit	Soluble in water.
Merck	14,2904
BRN	1723331
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. Solutions in water are not stable and must be used within 1 working day.
InChIKey	PMMURAAUARKVCB-CEZCPVKQSA-N
LogP	-1.460 (est)
CAS Datenbank	154-17-6(CAS DataBase Reference)
EPA chemische Informationen	D-arabino-Hexose, 2-deoxy- (154-17-6)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	20/21/22-36/37/38
S-Sätze:	24/25-37/39-36-26
WGK Germany	3
RTECS-Nr.	MQ3325000
F	3-10
TSCA	Yes
HS Code	29400090
Giftige Stoffe Daten	154-17-6(Hazardous Substances Data)

Gefahreninformationscode (GHS)

2-Deoxy-D-glucose Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
2-Deoxy-D-glucose (154-17-6) is a synthetic glucose analog with extensive biological effects. It is commonly thought of as an inhibitor of glycolysis, but its metabolic effects are wide-ranging. 2-Deoxy-D-glucose competitively inhibits glucose uptake via its metabolite 2-Deoxy-D-glucose-6-phosphate, which inhibits hexokinase and phosphoglucose-isomerase leading to decreased ATP production, cell cycle blockage, decreased cell growth and ultimately cell death.1,2
Chemische Eigenschaften
white to light yellow crystal powde
Verwenden
2-Deoxy-D-glucose (2-DG) is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
Verwenden
2-Deoxy-D-glucose is act as a culture media part in molecular genetics and as a targeted optical imaging agent for fluorescent in vivo imaging. It finds an application in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). It is utilized in the development of anti-cancer approaches like oxidative stress, radio and chemosensitization.
Verwenden
2-deoxy-D-Glucose is a non-metabolizable glucose analog that inhibits phosphorylation of glucose by hexokinase, the first step of glycolysis. This results in the depletion in cellular ATP, the inhibition of protein glycosylation, and the disruption of ER quality control by inducing the unfolded protein response. 2-deoxy-D-Glucose has been shown to cause cell cycle inhibition and cell death in in vitro models of hypoxia, induce autophagy, increase reactive oxygen species production, activate AMPK, and block tumor cell growth in animal models.[Cayman Chemical]
Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.
Sicherheitsprofil
Poison by subcutaneous route. Moderately toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits acrid smoke and fumes.
Lager
Store at +4°C
läuterung methode
Crystallise 2-deoxy--D-glucose from MeOH/Me2CO, Me2CO or butanone to give a mixture of and anomers, m 142-144o, [] 18 +38o (35minutes) to +46o (c 0.5, H2O). Recrystallisation from isoPrOH gives mainly the -anomer m 134-136o , [ ] D +156o to +103o (c 0.9, pyridine). 1H NMR studies showed that at 44o in D2O the solution contained 36% of -pyranose and 64% of -pyranose sugar, but furanose structures were undetectable. [Snowden & Fischer J Am Chem Soc 69 1048 1947, derivatives: Bollinger & Schmidt Helv Chim Acta 34 989 1951; see Angyal & Pickles Aust J Chem 25 1711 1972 for ratio of isomers in solution, Beilstein 1 IV 4282.]
Einzelnachweise
1) Ralser et al., (2008), A catabolic blockade does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth; Proc. Natl. Acad. Sci. USA 105 17807 2) Giammarioli et al. (2012), Differential effects of the glycolysis inhibitor 2-deoxy-D-glucose on the activity of pro-apoptotic agents in metastatic melanoma cells; Int. J. Cancer, 131 e337

2-Deoxy-D-glucose Upstream-Materialien And Downstream Produkte

2-Desoxy-D-glucose Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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