Veratrumsure

Bezeichnung:Veratrumsure

CAS-Nr93-07-2

Englisch Name:Veratric Acid

CBNumberCB0176264

SummenformelC9H10O4

Molgewicht182.17

MOL-Datei93-07-2.mol

Synonyma

Veratrumsure

Veratrumsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	179-182 °C(lit.)
Siedepunkt	275.56°C (rough estimate)
Dichte	1.2481 (rough estimate)
Brechungsindex	1.4500 (estimate)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	0.5g/l
Aggregatzustand	Crystalline Powder
pka	4.35±0.10(Predicted)
Farbe	Almost white to beige or reddish
Wasserlöslichkeit	slightly soluble
Merck	14,9953
BRN	518285
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	DAUAQNGYDSHRET-UHFFFAOYSA-N
LogP	1.610
CAS Datenbank	93-07-2(CAS DataBase Reference)
NIST chemische Informationen	Benzoic acid, 3,4-dimethoxy-(93-07-2)
EPA chemische Informationen	Benzoic acid, 3,4-dimethoxy- (93-07-2)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
RTECS-Nr.	DG8598750
TSCA	Yes
HS Code	29189090

Gefahreninformationscode (GHS)

Veratric Acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits and has antioxidant and anti-inflammatory activities. It also acts as a protective agent against hypertension-associated cardiovascular remodeling. Veratric acid reduces upregulated COX-2 expression and levels of PGE2 and IL-6 after UVB irradiation. This compound could be reduced to veratrine aldehyde, and alcohol was performed with enzyme extracts from a wood-degrading basidiomycete, Polystictus (Trametes) versicolor[1].
Chemische Eigenschaften
white to slightly yellow powder
Verwenden
3,4-Dimethoxybenzoic acid is a derivative of Protocatechuic Acid.3,4-Dimethoxybenzoic acid is a reagent used in the production of antimicrobial agents, antifeedants, and a variety of other biologically active compounds.
Verwenden
3,4-Dimethoxybenzoic acid plays an important role in producing antibiotics and various dyes. They are used as intermediates for pharmaceuticals (especially for antipyretic analgesic, antirheumatism) and other organic synthesis. It is used as matrix for ionization of peptides, proteins and carbohydrates.
Definition
ChEBI: A member of the class of benzoic acids that is benzoic acid substituted by methoxy groups at positions 2 and 3.
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 26, p. 299, 1978 DOI: 10.1248/cpb.26.299
Tetrahedron Letters, 43, p. 4985, 2002 DOI: 10.1016/S0040-4039(02)00929-2
in vitro
Veratric acid (100, 200 μM) suppresses iNOS expression in LPS-stimulated RAW264.7 cells. Veratric acid (200 μM) inhibits LPS-induced activation of the PI3K/Akt pathway, HAT activation, and HDAC3 expression in RAW264.7 cells.
Veratric Acid (10-100 μg/mL) has anti-inflammatory activity, protects HaCaT cells against UVB-mediated phototoxicity, increases S-phase cells, and prevents UVB-mediated apoptosis.
Veratric acid reduces upregulated COX-2 expression and levels of PGE2, and IL-6 after UVB irradiation.
läuterung methode
Crystallise the acid from Et2O, H2O or aqueous acetic acid. It has m 180-181o after sublimation at 80o/1mm. [Beilstein 10 H 393, 10 I 188, 10 II 261, 10 III 1404, 10 IV 1406.]
Einzelnachweise
[1] Gross, Georg G. “From lignins to tannins: Forty years of enzyme studies on the biosynthesis of phenolic compounds.” Phytochemistry 69 18 (2008): Pages 3018-3031.

Veratric Acid Upstream-Materialien And Downstream Produkte

Veratrumsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

93-07-2, Veratric Acid Verwandte Suche:

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