Testosteronpropionat

Bezeichnung:Testosteronpropionat

CAS-Nr57-85-2

Englisch Name:Testosterone propionate

CBNumberCB0158888

SummenformelC22H32O3

Molgewicht344.5

MOL-Datei57-85-2.mol

Synonyma

Testosteronpropionat

Testosteronpropionat physikalisch-chemischer Eigenschaften

Schmelzpunkt	118-123 °C
alpha	D25 +83 to +90° (100 mg in 10 ml dioxane)
Siedepunkt	419.57°C (rough estimate)
Dichte	1.0906 (rough estimate)
Brechungsindex	1.5000 (estimate)
storage temp.	Store at -20°C
Löslichkeit	ethanol: 10 mg/mL
Aggregatzustand	solid
Farbe	white
Biologische Quelle	synthetic (organic)
Wasserlöslichkeit	<0.1 g/100 mL at 24.5 ºC
Merck	13,9255
BRN	3221760
InChIKey	PDMMFKSKQVNJMI-BLQWBTBKSA-N
CAS Datenbank	57-85-2(CAS DataBase Reference)
NIST chemische Informationen	Androstene-17(beta)-propionate-3-one,delta8-(57-85-2)
EPA chemische Informationen	Testosterone propionate (57-85-2)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	45-22-63
S-Sätze:	53-36/37-45
RIDADR	2811
WGK Germany	3
RTECS-Nr.	XA3115000
HS Code	29372900
Toxizität	LD50 oral in rat: 1gm/kg

Gefahreninformationscode (GHS)

Testosterone propionate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R22:Gesundheitsschädlich beim Verschlucken.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Testosterone Propionate occurs as white or almost white powder or colourless to pale yellow, crystals or crystalline powder. It is freely soluble in methanol and in ethanol, and practically insoluble in water.
Verwenden
Testosterone propionate is an is an androgen and anabolic steroid (AAS) medication, which directs the development of the male phenotype during embryogenesis and at puberty. It has been widely used by athletes and bodybuilders for physical performance enhancement. Testosterone propionate has also been used for studying its effects on pregnant ewes.
Definition
ChEBI: Testosterone propionate is a steroid ester.
Trademarks
Andro heart injecta;Androfort;Androlan in oils;Cortrifosal;Durateston v;Encilcort;Galanrent;Gondrone;Gyno-terazol;Hermo m;Jeifer-old;Malogen in oil;Malotrone;Micro-sterandryl;Napionate;Orchisterone-p;Pantesin;Perandern;Pertesis;Sterotest;Sutanone;Tesrina;Testanderogen;Testenat;Testigrmon;Testilen;Testirene;Testoici;Testoidral;Testonate;Testopinate;Testo-retard;Testoviron (ampule);Testoviron-10/-25/-50;Testoviron-depot-50/-100;Testovis;Testron;Tostrina;Triomone;Vantostol-p;Viromon.
Weltgesundheitsorganisation (WHO)
In 1982, low dosage preparations of testosterone propionate, a synthetic ester of the naturally-occurring androgen, testosterone, were prohibited in Bangladesh following their inadmissable promotion as anabolic agents for use in malnourished children. Higher dosage preparations of testosterone propionate remain available in many countries, including Bangladesh, for several highly specific but limited indications including hypogonadism and the palliative treatment of inoperable breast cancer.
Allgemeine Beschreibung
Testosterone propionate appears as odorless white or yellowish-white crystals or a white or creamy-white crystalline powder. (NTP, 1992)
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
Testosterone propionate is sensitive to light. Incompatible with alkalis and oxidizing agents. .
Brandgefahr
Flash point data for Testosterone propionate are not available; however, Testosterone propionate is probably combustible.
Biochem/physiol Actions
Androgens direct the development of the male phenotype during embryogenesis and at puberty. Testosterone is an androgen that is secreted by the testis. This hormone is converted to dihydrotestosterone in the target tissues where it regulates several biological functions. Testosterone propionate has been synthetically derived from a plant. This product has extended and faster-acting functions when compared to other testosterone esters.
Sicherheitsprofil
with experimental neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by ingestion and wintraperitoneal routes. Human male reproductive effects by intramuscular and parenteral routes: changes in spermatogenesis, testes, epid~dpmis, and sperm duct. Human female reproductive effects by intramuscular and parenteral routes: menstrual cycle changes or disorders and effects on ferthty. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also TESTOSTERONE.
läuterung methode
Crystallise the propionate from aqueous EtOH, or Et2O/pet ether (m 121o), and it has max at 240nm (EtOH), and [] 20 +114o (c 1, CHCl3). Also purify it by HPLC. [Ercol & de Ruggieri J Am Chem Soc 75 650, 652 1953, polymorphism: Brandst.tter-Kuhnert & Kofler Mickokim Acta 847, 850 1959, Beilstein 8 IV 977.]
Mode of action
Testosterone Propionate is a short acting oil-based injectable formulation of testosterone. Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels. In addition, this agent promotes the maintenance of male sex characteristics and is indicated for testosterone replacement in hypogonadal males.

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