Donepezil

Bezeichnung:Donepezil

CAS-Nr120014-06-4

Englisch Name:Donepezil

CBNumberCB0156314

SummenformelC24H29NO3

Molgewicht379.49

MOL-Datei120014-06-4.mol

Donepezil physikalisch-chemischer Eigenschaften

Schmelzpunkt	207°C
Siedepunkt	527.9±50.0 °C(Predicted)
Dichte	1.141±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	Acetone (Slightly), Chloroform (Slightly)
Aggregatzustand	Solid
pka	8.84±0.10(Predicted)
Farbe	White to Off-White
Wasserlöslichkeit	2.931 mg/L
CAS Datenbank	120014-06-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-36/37/39
RIDADR	UN 2811
HS Code	29333990
Giftige Stoffe Daten	120014-06-4(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Donepezil Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Donepezil is another “nonclassic,” centrally acting, reversible, noncompetitive AChEI that was approved in 1997 for treatment of mild-to-moderate AD and dementia. Its selectivity for AChE is 570- to 1,250-fold that for butyrylcholinesterase, and it also exhibits greater affinity for brain AChE than for AChE in the periphery.
Verwenden
Donepezil is a cholinesterase inhibitors.
Verwenden
Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.[Cayman Chemical]
Definition
ChEBI: Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
Trademarks
Aricept (Eisai Medical Research).
Allgemeine Beschreibung
Donepezil, (±)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one (Aricept), commonly referred to in the literature asE2020, is a reversible inhibitor of AChE. It is indicated forthe treatment of symptoms of mild-to-moderate Alzheimerdisease. Donepezil is approximately 96% bound to plasmaproteins, with an elimination half-life of 70 hours. It is metabolizedprincipally by the 2D6 and 3A4 isozymes of theP450 system.
Stoffwechsel
When compared to tacrine, donepezil exhibits greater CNS AChE selectivity, longer elimination half-life (70–104 hours in subjects older than 55 years) and little or no potential for hepatotoxicity. Donepezil is metabolized by CYP2D6 and CYP3A4 via demethylation, debenzylation, hydroxylation, oxidation to the cis-N-oxide, and glucuronidation. The 6-O-desmethyl metabolite accounts for 11% of a dose, and it exhibits AChE inhibitory activity comparable to that of the parent compound.

Donepezil Upstream-Materialien And Downstream Produkte

Donepezil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

120014-06-4, Donepezil Verwandte Suche:

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