2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate

2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Asobamast,Onbio Inc.

• Verwenden

  Asobamast is a potent, orally active antiallergic agent that inhibits ige mediated passive pulmonary allergic responses in rats (ED50=4.7 mg/kg) and inhibits antigen-induced mediator release from sensitized guinea pig lung fragments[1].

• Manufacturing Process

  1). 179 mmol of bromine in 20 ml of chloroform were added dropwise in 10 minutes to a solution of 172 mmol of 3-methyl-5-acetylisoxazole, (Gass. Chim. Ital. 72, 242, 194) containing 4.9 ml of glacial acetic acid while the reaction mixture was maintained under stirring at 48°-50°C. After 5 minutes the mixture was poured into 300 g of water and crushed ice. The organic layer was separated, washed with water, dried and evaporated to residual 3- methyl-5-bromoacetylisoxazole. Yield 87%, white crystalline compound, MP: 44°-46°C (isopropyl ether).
  2). A mixture of 50 mmol of 3-methyl-5-bromoacetylisoxazole and 100 mmol of thiourea in 164 ml of ethyl alcohol was refluxed for 90 minutes and then cooled for 1 hour with an ice bath. The precipitate was collected by filtration and added to a mixture of 25 ml of a 10% aqueous solution of sodium hydroxide and 100 ml of ethyl acetate under vigorous stirring. The organic layer was separated, washed, dried and evaporated to dryness after recrystallization from acetonitrile the 2-amino-4-(3-methyl-5- isoxazolyl)thiazole melts at 208°-210°C. Yield, 57%.
  3). To a mixture of 20.5 mmol of 2-amino-4-(3-methyl-5-isoxazolyl)thiazole in 37.4 ml of pyridine maintained under stirring at 5°C were added dropwise 23.6 mmol of 2-ethoxyethyloxalyl chloride. The reaction mixture was maintained under stirring overnight, then poured into 100 g of crushed ice, made acid with concentrate hydrochloric acid and extracted with chloroform. The chloroform extracts were washed with water, dried and evaporated to dryness. The residual 2-ethoxyethyl-4-(3-methyl-5-isoxazolyl)thiazole-2- oxamate was re-crystallized from 65 ml of acetonitrile. Yield, 91%, MP: 155°- 156°C.

• Therapeutic Function

  Antiallergic, Anti-asthmatic

• Einzelnachweise

  [1] D Chiarino, et al. N-(4-Isoxazolylthiazol-2-yl)oxamic acid derivatives as potent orally active antianaphylactic agents. J Med Chem. 1991 Feb;34(2):600-5. DOI:10.1021/jm00106a020

2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate Upstream-Materialien And Downstream Produkte

2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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