5-(Hydroxymethyl)-2'-deoxycytidine Struktur

5-(Hydroxymethyl)-2'-deoxycytidine

Bezeichnung:5-(Hydroxymethyl)-2'-deoxycytidine

CAS-Nr7226-77-9

Englisch Name:5-(Hydroxymethyl)-2'-deoxycytidine

CBNumberCB01327931

SummenformelC10H15N3O5

Molgewicht257.24

MOL-Datei7226-77-9.mol

5-(Hydroxymethyl)-2'-deoxycytidine physikalisch-chemischer Eigenschaften

Schmelzpunkt	205°C(lit.)
Siedepunkt	575.0±60.0 °C(Predicted)
Dichte	1.480 g/cm3
storage temp.	Store at -20°C
Löslichkeit	DMF: 5 mg/ml; DMSO: 20 mg/ml; PBS (pH 7.2): 10 mg/ml
Aggregatzustand	powder to crystal
pka	13.47±0.10(Predicted)
Farbe	White to Light yellow
maximale Wellenlänge (λmax)	274nm(H2O)(lit.)
InChI	InChI=1S/C10H15N3O5/c11-9-5(3-14)2-13(10(17)12-9)8-1-6(16)7(4-15)18-8/h2,6-8,14-16H,1,3-4H2,(H2,11,12,17)/t6-,7+,8+/m0/s1
InChIKey	HMUOMFLFUUHUPE-XLPZGREQSA-N
SMILES	OC[C@H]1O[C@@H](N2C=C(CO)C(N)=NC2=O)C[C@@H]1O
CAS Datenbank	7226-77-9

Sicherheit

HS Code

2934.99.4400

Gefahreninformationscode (GHS)

5-(Hydroxymethyl)-2'-deoxycytidine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine) and occurs almost exclusively in CpG islands. Another epigenetic modification in DNA has been recently identified that involves hydroxymethylation of this same base (5-hydroxymethylcytosine), which potentially offers another level of transcriptional control. 5-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA and has been used to quantify DNA hydroxymethylation levels in biological samples.
Verwenden
5-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA and has been used to quantify DNA hydroxymethylation levels in biological samples.[Cayman Chemical]
Biologische Funktion
5-(hydroxymethyl)-2'-deoxycytidine (5-hmdC), the oxidative product from 5- (methyl)-2'-deoxycytidine (5-mdC) by TET protein, plays critical roles in a variety of physiological processes such as DNA demethylation, cellular differentiation, and epigenetic regulation, etc. In addition, 5-hmdC has also been demonstrated as a potential biomarker reflecting the diagnosis and prognosis of multiple diseases. Some studies have reported that the level of 5-hmdC significantly decreases in diversified cancers, which suggests its important role in tumor formation and development. In 2009, breakthrough studies found that the 5-hmdC is not the unique oxidative product of 5-mdC. 5-(hydroxymethyl)-2'-deoxycytidine is a crucial intermediate product of the DNA demethylation pathway, which can act as potential biomarkers reflecting the diagnosis and prognosis in multiple tumors. 5-hmdC in human urine is in the form of single deoxynucleosides produced by DNA degradation or metabolism, which can avoid digestion. 5-hmdC has been identified in human urine[1].
Einzelnachweise
[1] Mengzhe Guo. “Enrichment and Quantitative Determination of 5-(Hydroxymethyl)-2′-deoxycytidine, 5-(Formyl)-2′-deoxycytidine, and 5-(Carboxyl)-2′-deoxycytidine in Human Urine of Breast Cancer Patients by Magnetic Hyper-Cross-Linked Microporous Polymers Based on Polyionic Liquid.” Analytical Chemistry 90 6 (2018): 3906–3913.

5-(Hydroxymethyl)-2'-deoxycytidine Upstream-Materialien And Downstream Produkte

5-(Hydroxymethyl)-2'-deoxycytidine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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