Botiacrine

Botiacrine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Botiacrine,ZYF Pharm Chemical

• Manufacturing Process

  To 1 gramm-equivalent (g-eq) of dimethylaminoethanethiol in 150 ml of ether, a suspension of g-eq of 50% sodium hydride in 50-ml of anhydrous ether was added. After boiling for 1 hour, the reaction mixture was cooled to 0°C, whereupon g-eq of 9,9-dimethylacridan-10-carboxylic acid chloride (prepared from 9,9-dimethylacridan and phosghene - cf. Swiss Specification No. 426,821) were added and the mixture was heated for a further 6 hours to boiling temperature. After cooling to ambient temperature, the precipitated sodium chloride was filtered in a Buchner funnel fitted with a filter cell. The corresponding 9,9-dimethylacridan-10-carboxylic aciddimethylaminoethanethiol ester was immediately precipitated out of filtrate as base, which melted at 110.5°-111°C. Ethanesulphonic acid salt melted at 147°-150°C.

• Therapeutic Function

  Antiparkinsonian

Botiacrine Upstream-Materialien And Downstream Produkte

Botiacrine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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