BRD-7539

BRD-7539 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  BRD7539B is a Dihydroorotate dehydrogenase (DHODH) inhibitor . RD7539 had shown to target PfDHODH (IC50 = 0.033 μM) selectively over human (Hs) DHODH (IC50 > 50 μM). BRD7539 was reported to have potent activity against both multidrug-resistant asexual blood-stage (P. falciparum, Dd2_x000D_ strain, EC50 = 0.010 μM) and liver-stage (P. berghei, EC50 =0.015 μM) parasites but no activity against sexual blood-stage (P. falciparum, stages IV?V, EC50 > 20 μM) parasites. BRD7539 is an azetidine carbonitrile with three contiguous stereocenters (2S,3S,4S), and stereochemistry-based structure?_x000D_ activity relationships (SSARs) showed that only two of eight possible stereoisomers are active.

BRD-7539 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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