Alibendol

Alibendol Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  White Solid

• Originator

  Cebera ,Bouchara ,France ,1981

• Verwenden

  An amide analog of Eugenol, and is used therapeutically as an antispasmodic.

• Verwenden

  Alibendol is an antispasmodic,choleretic, and cholekinetic.

• Definition

  ChEBI: Alibendol is a member of salicylamides.

• Manufacturing Process

  36 g of ethyl ester of 2-hydroxy-3-methoxy-5-allyl-benzoic acid [obtained by the process described by Pearl, et al., J. Amer. Chem. Soc., Vol. 71, 1067- 1068 (1949)] and 61 g of ethanolamine were admixed and left to stand for 1 hour at ambient temperature after which it was heated for 1 hour at 120°C. The mixture was extracted with chloroform and the organic phases were washed with half diluted hydrochloric acid, then with water, and the chloroform evaporated off. The residue, after recrystallization from benzene, was a 78% yield of 2-hydroxy-3-methoxy-5-allyl-N-(β-hydroxyethyl)- benzamide having a melting point of 95°C. The product appeared in the form of colorless crystals which were insoluble in water and soluble in dilute sodium hydroxide.

• Therapeutic Function

  Choleretic, Spasmolytic

Alibendol Upstream-Materialien And Downstream Produkte

Alibendol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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