1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-

1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]- Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM[1]. STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells[1].STING agonist-12 is not active at mouse STING[1]. STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life[1].

• Lager

  Store at -20°C

• Einzelnachweise

  [1]. Pryde DC, et al. The discovery of potent small molecule activators of human STING. Eur J Med Chem. 2021 Jan 1;209:112869.

1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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