Seneciphylline

Bezeichnung:Seneciphylline

CAS-Nr480-81-9

Englisch Name:Seneciphylline

CBNumberCB0103055

SummenformelC18H23NO5

Molgewicht333.38

MOL-Datei480-81-9.mol

Seneciphylline physikalisch-chemischer Eigenschaften

Schmelzpunkt	217°C
alpha	D -128° (chloroform)
Siedepunkt	470.34°C (rough estimate)
Dichte	1.2467 (rough estimate)
Brechungsindex	1.5740 (estimate)
storage temp.	-20°C
Löslichkeit	DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.1 mg/ml
pka	12.43±0.20(Predicted)
Stabilität	Stable, but reacts with oxygen in the air. Incompatible with alkali, oxidizing agents. Store under inert gas.
LogP	0.810 (est)
CAS Datenbank	480-81-9
IARC	3 (Vol. 10, Sup 7) 1987
EPA chemische Informationen	Seneciphylline (480-81-9)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/24/25-25
S-Sätze:	1-20-24/25-45
RIDADR	1544
WGK Germany	3
HazardClass	6.1(b)
PackingGroup	III
Giftige Stoffe Daten	480-81-9(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Seneciphylline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S1:Unter Verschluss aufbewahren.
S20:Bei der Arbeit nicht essen und trinken.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Seneciphylline, a pyrrolizidine alkaloid, one of the main components of Chinese medicine herb Tusanqi, which is a reason of the hepatic sinusoidal obstruction syndrome (HSOS). In addition, experiments on rats have shown that seneciphylline had adverse effects on the development and organic morphodifferentiation of embryos, thus the pregnant people exposed to Hebra may get potential risk on the fetus.
Chemische Eigenschaften
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, Derived from the whole plant or root of Gynura segetum (Lour.) Merr (Ju Sanqi).
Verwenden
Seneciphylline is a minor constituent of S. jacobaea, which has been used as a medicinal herb in Europe. It has the effect of coagulation and hemostasis.
Seneciphylline is a pyrrolizidine alkaloid with the potential to affect hepatic drug metabolizing enzymes in rat cells.
Application
Seneciphylline is a naturally occurring plant toxin, which is employed to defend the plant against herbivore and insect attacks.
Seneciphylline may be used as an analytical reference standard for the quantification of the analyte in feed samples and traditional Chinese herbal medicines using different chromatography techniques.
Definition
ChEBI: LSM-2853 is a citraconoyl group.
Air & Water Reaktionen
Reacts slowly with atmospheric oxygen. . Insoluble in water.
Reaktivität anzeigen
SENECIPHYLLIN is readily hydrolyzed with alkali; SENECIPHYLLIN reacts readily with oxidizing agents .
Health Hazard
Seneciphylline and aflatoxin B. may be of greater importance as a cause of human disease than the presently known outbreaks of poisoning would indicate.
SYMPTOMS: Symptoms associated with this compound include abdominal pain, nausea and diarrhea, emaciation, intestinal edema and congestion of the liver. ACUTE/CHRONIC HAZARDS: Very toxic. (NTP, 1992)
Brandgefahr
Flash point data are not available for SENECIPHYLLIN, but SENECIPHYLLIN is probably combustible.

Seneciphylline Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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