雄酮

睾酮代谢物生物活性靶点体外研究体内研究雄酮试剂级价格

雄酮

CAS号:53-41-8
英文名:Androsterone
中文名:雄酮
CBNumber:CB9853748
分子式:C19H30O2
分子量:290.44
MOL File:53-41-8.mol

雄酮化学性质

熔点 :181-184 °C(lit.)
比旋光度 :96 º (c=1, C2H5OH)
沸点 :372.52°C (rough estimate)
密度 :1.0320 (rough estimate)
折射率 :1.4709 (estimate)
储存条件 :−20°C
溶解度 :Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
酸度系数(pKa) :15.14±0.60(Predicted)
水溶解性 :11.5mg/L(23.5 ºC)
Merck :13,645
BRN :2217626
CAS 数据库 :53-41-8(CAS DataBase Reference)
NIST化学物质信息 :Androsterone(53-41-8)
EPA化学物质信息 :Androsterone (53-41-8)

安全信息

危险品标志 :Xi
危险类别码 :36/37/38-43
安全说明 :22-24/25-36/37-26
WGK Germany :3
RTECS号 :BV8053000
F :3-21
海关编码 :29379000

雄酮 MSDS

Androstan-3a-ol-17-one

雄酮性质、用途与生产工艺

睾酮代谢物雄酮 androsterone，即3α-羟-5d-雄烷-17-酮。是由男性尿中检出的睾酮代谢物之一。是以葡糖醛酸抱合体的形式而排出于尿中。其雄性激素作用弱于睾酮。表雄酮（epian-drosterone）是在3β位上有羟基的异构物。
生物活性 Androsterone (5alpha-Androsterone)是源于性激素的类固醇代谢产物，具有较弱的雄激素属性。
靶点

Human Endogenous Metabolite
体外研究

Androsterone activates both the mFXR-LBD and the hFXR-LBD, with Androsterone activating the mFXR-LBD more strongly than the hFXR-LBD. Furthermore, cotransfection studies with gal4-hFXR-LBD and SRC-1/VP16 expression plasmids demonstrate that Androsterone potentiates the interaction of SRC-1 with the hFXR-LBD. Several amino acid changes including H294S, S332V, R351H, and Y361F significantly reduce Androsterone activation. Androsterone (5α, 3α-A) (10 to 100 μM) also inhibits epileptiform discharges in a concentration-dependent fashion in the in vitro slice model.
体内研究

Androsterone treatment results in a significant induction of small heterodimer partner (SHP), suggesting Androsterone may activate endogenous FXR. Intraperitoneal injection of Androsterone (5α, 3α-A) protects mice in a dose-dependent fashion from seizures in the following models (ED ₅₀ , dose in mg/kg protecting 50% of animals): 6 Hz electrical stimulation (29.1), pentylenetetrazol (43.5), pilocarpine (105), 4-AP (215), and maximal electroshock (224).