6-硝基-2-氨苯酚-4-磺酸

IC50: 297 nM ( Plasmodium falciparum );
Ornithine aminotransferase

L-Canaline treatment inhibits the proliferation of PBMCs after stimulation by phorbol 12-myristate-13-acetate (PMA) or via the mixed lymphocyte reaction. The greatest effect is seen with PMA-stimulated cells, where L-canaline has an IC ₅₀ of 0.26 mM. L-Canaline is slightly less toxic to PBMCs stimulated via the mixed lymphocyte reaction ( IC ₅₀ of 0.54 mM). L-canaline inhibits L-lysine flux competitively ( K _i of 4.6 mM) in astrocytes and astrocytoma cells.

L-Canaline decreases the aspartic acid content of tissues of the medulla oblongata of male Wistar rats, but it does not affect the evoked release of this nonprotein amino acid into these tissues.
Intraseptal injection of 100 μg of L-canaline into male Sprague-Dawley rats causes a 90% decrease in the omithine aminotransferase activity of the septum tissues evaluated from animals killed 1 h later.