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ChemicalBook CAS数据库列表 CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE

CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE

生物活性体外研究体内研究 CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE 试剂级价格

CAS号:153088-73-4
英文名:Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE
中文名:CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
CBNumber:CB8336473
分子式:C20H17Cl2NO7
分子量:454.26
MOL File:153088-73-4.mol

CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE化学性质

沸点 :674.2±55.0 °C(Predicted)
密度 :1.440±0.06 g/cm3(Predicted)
储存条件 :−20°C
溶解度 :Soluble in DMSO (up to 25 mg/ml).
形态 :White to off-white powder.
酸度系数(pKa) :4.01±0.19(Predicted)
颜色 :white
稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

安全信息

WGK Germany :3

CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE性质、用途与生产工艺

生物活性 Z-Asp-CH2-DCB 是一种不可逆的广谱 caspase 抑制剂，Z-Asp-CH2-DCB 也能抑制具有 caspase 样活性的蛋白酶。Z-D-CH2-DCB 并以剂量依赖的方式阻断 PBMC 细胞中的金黄色葡萄球菌肠毒素 B (SEB) 刺激的 IL-1β、TNF-α、IL-6 和 IFN-γ 的产生，和降低 SEB-1 刺激的 T 细胞增殖。Z-Asp-CH2-DCB 可预防 SU5416 诱导的间隔细胞凋亡和肺气肿的发生。

体外研究

Z-Asp-CH2-DCB (10-100 μM) blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in SEB-stimulated (200 ng; 16 hours) PBMC in a dose-dependent manner. The production of the chemokines MCP-1, MIP-1α, and MIP-1β was also suppresses. The inhibitory effect of Z-Asp-CH2-DCB on TSST-1-activated PBMC is similar, reducing IL-1β, IL-6, TNF-α, IFN-γ, MCP-1, MIP-1α, and MIP-1β to 10, 36, 25, 10, 11, 25, and 30%, respectively, of levels in untreated cells.
Z-Asp-CH2-DCB (10-100 μM; 48 hours) inhibits T-cell proliferation in PBMC stimulated with 200 ng of SEB/ml .

Cell Viability Assay

Cell Line:	Human peripheral blood mononuclear cells
Concentration:	10, 50, 100 μM
Incubation Time:	48 hours
Result:	Inhibited T-cell proliferation in PBMC stimulated with SEB.

体内研究

Z-Asp-CH2-DCB (1 mg; i.p.; every day for 3 weeks) prevents SU5416-induced septal cell apoptosis.

Animal Model:	Male Sprague-Dawley rats (SU5416+ Z-Asp-CH2-DCB group)
Dosage:	1 mg
Administration:	Intraperitoneal injection; every day for 3 weeks
Result:	The caspase 3-like activity in SU5416-treated rat lungs is significantly higher, whereas lungs from rats treated with SU5416+Z-Asp-CH2-DCB showed no increase in apoptotic activity.