1-甲基-4-苯基-1,2,3,6-四氢吡啶

1-甲基-4-苯基-1,2,3,6-四氢吡啶化学性质

熔点 :aprox. 36°C
沸点 :128-132 °C12 mm Hg(lit.)
密度 :1.001±0.06 g/cm3(Predicted)
储存条件 :Inert atmosphere,Room Temperature
溶解度 :Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)
形态 :Solid
酸度系数(pKa) :8.66±0.40(Predicted)
颜色 :Pale Yellow to Light Yellow
Merck :13,6319
稳定性 :Stable. Incompatible with strong oxidizing agents.

安全信息

危险品标志 :T
危险类别码 :25-39/23/24/25
安全说明 :45
危险品运输编号 :UN 2811 6.1/PG 2
WGK Germany :3
RTECS号 :UT8358900
危险等级 :6.1(b)
包装类别 :III
毒害物质数据 :28289-54-5(Hazardous Substances Data)
毒性 :Human toxicity originally discovered when it was an unexpected by-product from the illicit synthesis of a heroin substitute (i.e., meperidine analog). Currently used experimentally as the primary animal model for the study of Parkinson’s disease. MPTP is a neurotoxicant that is activated to 1-methyl-4-phenylpyridinium ion (MPP1) by the actions of monoamine oxidase B located in the mitochondria of brain astrocytes. The MPP1 is then transported into dopamine, and to a lesser extent, other monoaminergic neurons. Once inside these dopamine neurons in the substantia nigra, it destroys these neurons by mechanisms that may involve an oxidative cascade and/or inhibition of electron transport. Intoxication causes a parkinsonism syndrome almost identical in signs and symptoms to Parkinson’s disease, including rigidity, bradykinesia, tremor, and postural instability. In the event of known ingestion, immediate (but not delayed) administration of a monoamine oxidase inhibitor (especially one selective for MAO-B like deprenyl) and dopamine uptake inhibitor can be therapeutic.

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