ChemicalBook CAS数据库列表 1-(4-溴苄基)吲哚-2,3-二酮
1-(4-溴苄基)吲哚-2,3-二酮
- CAS号:79183-37-2
- 英文名:1-(4-BROMOBENZYL)INDOLE-2,3-DIONE
- 中文名:1-(4-溴苄基)吲哚-2,3-二酮
- CBNumber:CB82463915
- 分子式:C15H10BrNO2
- 分子量:316.15
- MOL File:79183-37-2.mol
1-(4-溴苄基)吲哚-2,3-二酮化学性质
- 熔点 :178-180 °C
- 沸点 :469.2±47.0 °C(Predicted)
- 密度 :1.604±0.06 g/cm3(Predicted)
- 储存条件 :Sealed in dry,Room Temperature
- 溶解度 :DMSO: 50 mg/mL (158.15 mM)
- 形态 :A solid
- 酸度系数(pKa) :-2.61±0.20(Predicted)
- 颜色 :Orange to red
1-(4-溴苄基)吲哚-2,3-二酮性质、用途与生产工艺
- 生物活性 VU0119498 是一种泛Gq muscarinic acetylcholine receptor (mAChR) M1，M3，M5的正向变构调节剂(PAM)，对应EC50值分别为6.1 μM, 6.4 μM, 4.1 μM。
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靶点
Target Value mAChR M5
(Cell-free assay)4.1 μM mAChR M1
(Cell-free assay)6.1 μM mAChR M3
(Cell-free assay)6.4 μM -
体外研究
VU0119498 (0.01-30 μM; 150 s) potentiates Ach responses in M1, M3, and M5-expressing CHO cells, with EC 50 s of 6.04, 6.38, and 4.08 µM, respectively.
VU0119498 (3-20 μM) augments ACh-mediated increasing in insulin secretion and intracellular calcium levels in MIN6-K8 cells.
VU0119498 (20 μM; 90 min) enhances ACh-induced insulin release in mouse and human pancreatic islets. -
体内研究
VU0119498 (0.1-2 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in mice in a β-cell M3R-dependent fashion.
VU0119498 (0.5 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in obese, glucose-intolerant mice.Animal Model: Male WT mice (12 weeks) Dosage: 0.1, 0.5, 2 mg/kg Administration: A single i.p. Result: Caused a significant improvement in glucose tolerance at the dose of 0.5 mg/kg.
Significantly augmented GSIS at the dose of 0.5 mg/kg.
1-(4-溴苄基)吲哚-2,3-二酮上下游产品信息
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1-(4-溴苄基)吲哚-2,3-二酮 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-114933
- 产品名称：VU0119498
- CAS编号：
- 包装：5 mg
- 价格：375元
- 更新日期：2024/11/08
- 产品编号：HY-114933
- 产品名称：1-(4-溴苄基)吲哚-2,3-二酮 VU0119498
- CAS编号：79183-37-2
- 包装：10mg
- 价格：600元
1-(4-溴苄基)吲哚-2,3-二酮生产厂家
- 公司名称：VITAS-BB
- 联系电话：--
- 电子邮件：
- 国家：俄罗斯
- 产品数：6753
- 优势度：64
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