硫培南

用途靶点体外研究体内研究硫培南试剂级价格

硫培南

CAS号:120788-07-0
英文名:Sulopenem
中文名:硫培南
CBNumber:CB81116702
分子式:C12H15NO5S3
分子量:349.45
MOL File:120788-07-0.mol

硫培南化学性质

沸点 :693.1±55.0 °C(Predicted)
密度 :1.74±0.1 g/cm3(Predicted)
储存条件 :Store at -20°C
酸度系数(pKa) :3.88±0.40(Predicted)
形态 :Solid
颜色 :White to yellow

硫培南性质、用途与生产工艺

用途
硫培南是一种具有口服活性的肠胃外青霉烯类抗生素，对革兰氏阳性菌和革兰氏阴性菌具有广谱活性。它可用于尿路感染和腹腔内感染的研究，它对铜绿假单胞菌和嗜黄单胞菌的嗜麦芽孢杆菌无效。
靶点

MIC: 0.015-0.12 µg/mL ( E. coli )
体外研究

Sulopenem has the potential for uncomplicated and complicated urinary tract infections and intra-abdominal infections treatment, including multidrug-resistant (MDR) infections and infections attributable to quinolone-nonsusceptible and/or extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacilli.
Sulopenem inhibits the growth of most isolates of aerobic and anaerobic Gram-positive and Gram-negative bacteria, including methicillin-susceptible Staphylococcus aureus , Streptococcus pneumoniae (penicillin-susceptible and -resistant isolates), group A and B β-hemolytic streptococci, Listeria monocytogenes , Enterobacteriaceae , Haemophilus influenzae , and Moraxella catarrhalis but excluding P. aeruginosa and Stenotrophomonas maltophilia , at a concentration of ≤1 μg/mL.
体内研究

The protective effects of Sulopenem in murine experimental systemic infections are superior to those of Imipenem/Cilastatin. In murine experimental mixed infection with Escherichia coli and Bacteroides fragilis , Sulopenem has lower ED ₅₀ . In guinea pigs experimental lung infection with Klebsiella pneumoniae , Sulopenem is more effective than CZON or Cefotiam.