泮托拉唑钠水合物

生物活性体外研究体内研究泮托拉唑钠水合物试剂级价格

泮托拉唑钠水合物

CAS号:164579-32-2
英文名:PantoprazoleSodiumSesquihydrate
中文名:泮托拉唑钠水合物
CBNumber:CB71075156
分子式:C16H18F2N3NaO5S
分子量:425.38
MOL File:164579-32-2.mol

泮托拉唑钠水合物化学性质

储存条件 :4°C, protect from light
溶解度 :Freely soluble in water and in ethanol (96 per cent), practically insoluble in hexane.
形态 :Solid
颜色 :White to off-white

安全信息

危险品标志 :Xn
危险类别码 :22
WGK Germany :nwg
海关编码 :2933399090

泮托拉唑钠水合物性质、用途与生产工艺

生物活性 Pantoprazole sodium hydrate (BY1023 sodium hydrate) 是一种具有口服活性的，有效质子泵 (proton pump) 抑制剂 (PPI)。Pantoprazole sodium hydrate 是一种取代的苯并咪唑，是一种有效的 H+/K+-ATPase 抑制剂，IC50 为 6.8 μM。Pantoprazo sodium hydrate 可以改善 pH 值稳定性，并具有抗分泌，抗溃疡的作用。Pantoprazo sodium hydrate 联合阿霉素 (Doxorubicin; HY-15142) 可显着增加肿瘤生长延迟。
体外研究

Pantoprazole sodium hydrate (BY1023 sodium hydrate; 1-10000 μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells.
Pantoprazole sodium hydrate can block exosome release. Pantoprazole sodium hydrate inhibits the activity of V-H ⁺ -ATPase and impaires the ability of tumour cells (melanomas, adenocarcinomas, and lymphoma cell lines) to acidify the extracellular medium

体内研究

Pantoprazole sodium hydrate (BY1023 sodium hydrate; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin.
Pantoprazole sodium hydrate (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats.

Animal Model:	Mice bearing MCF-7 or A431 xenografts
Dosage:	200 mg/kg
Administration:	IP; once a week for 3 weeks; alone or 2 hours before Doxorubicin (6 mg/kg i.v.)
Result:	Showed even greater growth delay of MCF-7 xenografts with Doxorubicin compared with the single-dose combination. Significantly increased tumor growth delay with a single dose with Doxorubicin. There is no effect on growth delay alone.