吡啶酮乙醇胺盐

简介用途生物活性靶点体外研究体内研究吡啶酮乙醇胺盐试剂级价格

吡啶酮乙醇胺盐

CAS号:68890-66-4
英文名:Piroctone olamine
中文名:吡啶酮乙醇胺盐
CBNumber:CB6433396
分子式:C16H30N2O3
分子量:298.43
MOL File:68890-66-4.mol

吡啶酮乙醇胺盐化学性质

熔点 :134.0 to 138.0 °C
沸点 :135-235℃[at 101 325 Pa]
密度 :1.1[at 20℃]
蒸气压 :0-0Pa at 20-25℃
储存条件 :Inert atmosphere,2-8°C
溶解度 :Chloroform (Slightly, Sonicated), Methanol (Slightly)
酸度系数(pKa) :5.9-7.4[at 20 ℃]
颜色 :White to Off-White
水溶解性 :400-50000mg/L at 20-25℃
Merck :14,7502
InChI :InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
InChIKey :BTSZTGGZJQFALU-UHFFFAOYSA-N
SMILES :C(N)CO.C(C1=CC(C)=CC(=O)N1O)C(C)CC(C)(C)C
LogP :1.05-3.86 at 20-25℃
CAS 数据库 :68890-66-4(CAS DataBase Reference)

安全信息

WGK Germany :2
RTECS号 :UU7786150
海关编码 :2933399090

吡啶酮乙醇胺盐性质、用途与生产工艺

简介
吡罗克酮乙醇胺盐独特的性能主要表现在：
1. 去屑止痒效果优于同类产品。
2. 溶解性能、复配性能优良，与化妆品原料混合不会发生沉淀或分层现象。
3. 去屑机理独特，刺激性极低，不会引起脱发、断发，安全性优于同类去屑止痒产品。
用途羟吡酮是一种高效、无毒无刺激的去屑剂，可以广泛使用于去屑香波、养发液和护发素等洗护类化妆品中。
生物活性
吡啶酮乙醇胺盐是一种吡啶衍生物。具有杀真菌作用。
靶点

Antifungal
体外研究

Piroctone olamine, the ethanolamine salt of the hydroxamic acid derivative Piroctone, is a hydroxypyridone anti-mycotic agent. Piroctone olamine penetrates the cell membrane and forms complexes with iron ions, inhibiting energy metabolism in mitochondria. Piroctone olamine (PO) is an ethanolamine salt of the hydroxamic acid derivative Piroctone. All Candida strains show low minimum inhibitory concentrations (MICs) for Piroctone olamine (0.125-0.5 μg/mL) and Amphotericin B (AMB) (0.03-1 μg/mL).
体内研究

This work aimed to evaluate the antifungal activity of Piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The treatment with Piroctone olamine (0.5 mg/kg) is performed 72 h after infection by intraperitoneal administration. For comparison, a group of animals (n=6) is treated with Amphotericin B (0.5 mg/kg). The mycological diagnosis is made by collecting the liver, spleen and kidneys. Data regarding the fungal growth and mortality are analyzed statistically by Student’s t test and analysis of variance, with level of significance set at P<0.05. The difference in fungal growth scoring between the control group and the treatment groups (Piroctone olamine and Amphotericin B) is statistically significant (P<0.05).