N-乙酰-2-苄基色胺
- CAS号:117946-91-5
- 英文名:LUZINDOLE
- 中文名:N-乙酰-2-苄基色胺
- CBNumber:CB6268781
- 分子式:C19H20N2O
- 分子量:292.37
- MOL File:117946-91-5.mol
- 熔点 :44-46°C
- 沸点 :434.31°C (rough estimate)
- 密度 :1.1045 (rough estimate)
- 折射率 :1.6140 (estimate)
- 储存条件 :-20°C
- 溶解度 :DMSO: 5 mg/mL
- 形态 :White to off-white crystalline solid.
- 酸度系数(pKa) :16.36±0.46(Predicted)
- 颜色 :Off-White to Yellow
- 水溶解性 :Soluble in DMSO (100 mM), ethanol (100 mM), chloroform, methanol, and water.
- 稳定性 :Store at -20°C
- CAS 数据库 :117946-91-5(CAS DataBase Reference)
- 安全说明 :24/25
- WGK Germany :3
- RTECS号 :AC7765700
- 海关编码 :29339980
N-乙酰-2-苄基色胺性质、用途与生产工艺
- 生物活性 Luzindole (N-0774) 是一种选择性褪黑素受体 (melatonin receptor) 拮抗剂。Luzindole 优先靶向 MT2 (Mel1b)，对于人 MT2 和 MT1 的 Ki 值分别为 10.2 和 158 nM。Luzindole 抑制实验性自身免疫性脑脊髓炎，并发挥抗抑郁样活性。
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靶点
Ki :10.2 nM (human MT2), 158 nM (human MT1)
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体外研究
Luzindole (N-0774) (5-10 μg/ml) inhibits antigen-specific proliferation of the MBP-reactive LV-4 T cell line.
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体内研究
Luzindole (N-0774) (30 mg/kg; i.p.; days 0-5) suppresses experimental autoimmune encephalomyelitis.
Luzindole (N-0774) (30 mg/kg i.p.) reduces the time of immobility in a dose-dependent manner, the effect being more pronounced at midnight (60% reduction) than at noon (39% reduction). The effect of luzindole is time-dependent, showing a maximal effect at 60 min. The anti-immobility effect of luzindole (10 mg/kg i.p.) is prevented by the administration of melatonin (30 mg/kg i.p.). Luzindole (30 mg/kg i.p.) did not modify the time of immobility either at noon or midnight in the albino ND/4 mouse, or in the C57BL/6J mouse, which does not produce melatonin.Animal Model: Twenty-three- to 12-week-old(SJL X PL/J ) F1 mice Dosage: 30 mg/kg Administration: i.p.; days 0-5 (between 23: 00 and 1: 00 under conditions of minimal lighting) Result: Effectively prevented experimental autoimmune encephalomyelitis.
- 更新日期：2024/11/08
- 产品编号：HY-101254
- 产品名称：N-乙酰-2-苄基色胺 Luzindole
- CAS编号：117946-91-5
- 包装：1mg
- 价格：760元
- 更新日期：2024/11/08
- 产品编号：HY-101254
- 产品名称：N-乙酰-2-苄基色胺 Luzindole
- CAS编号：117946-91-5
- 包装：5mg
- 价格：1900元
- 公司名称：Acros Organics
- 联系电话：--
- 电子邮件：info@acros.com
- 国家：比利时
- 产品数：6772
- 优势度：81
