山卓霉素

生物活性靶点体外研究体内研究山卓霉素试剂级价格

山卓霉素

CAS号:100940-65-6
英文名:sandramycin
中文名:山卓霉素
CBNumber:CB61357149
分子式:C60H76N12O16
分子量:1221.32
MOL File:100940-65-6.mol

山卓霉素化学性质

储存条件 :Store at -20°C
溶解度 :Soluble in DMSO
形态 :solid

安全信息

海关编码 :29419000

山卓霉素性质、用途与生产工艺

生物活性 Sandramycin 是一种从 Nocardioides sp 的培养液中分离出来的一种环状十肽抗菌素。Sandramycin 也可以有效地结合 DNA，并且是一种 ADC 的毒素分子。Sandramycin 对革兰氏阳性细菌 (Gram-positive bacteria) 具有活性，并具有有效的抗肿瘤活性。
靶点

Traditional Cytotoxic Agents
体外研究

Sandramycin has antimicrobial activity wtih MIC values of 0.024 μg/mL, 0.012 μg/mL, 0.012 μg/mL, 0.098 μg/mL, 0.024 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Bacillus subtilis (Rec ⁺ ) A22508-2, B. subtilis (Rec ^- ) A22509-2-2, Staphylocccus aureus 209P-A9497, S. aureus (echinomycin-resistant) A9628, Streptococcus faecalis A96 1 1, Escherichia coli A151 19 and E. coli (actinomycin-sensitive) A21780 (AS-19), respectively.
Sandramycin inhibits cancer cells growth of L1210, B16, HCT118, RPMI8226, A431, RKO, SU-DHL6 and SU-DHL10 cells with IC ₅₀ values of 0.02 nM, 0.07 nM, 0.8 nM, 3.8 nM, 3.1 nM, 1.3 nM, 5.9 nM and 3.3 nM, respectively.

体内研究

Sandramycin (0.0125-1.6 mg/kg; intraperitoneal injection; daily; for 5 days; CDF1 female mice) treatment shows moderately active in vivo against leukemia P388 in mice.

Animal Model:	CDF1 female mice injected with leukemia P388 cells
Dosage:	0.0125 mg/kg, 0.025 mg/kg, 0.05 mg/kg, 0.1 mg/kg, 0.2 mg/kg, 0.4 mg/kg, 0.8 mg/kg, 1.6 mg/kg
Administration:	Intraperitoneal injection; daily; for 5 days
Result:	Was moderately active in vivo against leukemia P388 in mice.