CS-2408
- CAS号:148081-72-5
- 英文名:1-O-Hexyl-2,3,5-trimethylhydroquinone
- 中文名:CS-2408
- CBNumber:CB61175507
- 分子式:C15H24O2
- 分子量:236.35
- MOL File:148081-72-5.mol
- 熔点 :72.5-73°C
- 沸点 :357.8±37.0 °C(Predicted)
- 密度 :0.971±0.06 g/cm3(Predicted)
- 储存条件 :Inert atmosphere,2-8°C
- 溶解度 :Chloroform：soluble
- 形态 :powder to crystal
- 酸度系数(pKa) :11.22±0.30(Predicted)
- 颜色 :White to Light yellow to Dark green
- LogP :5.255 (est)
- 海关编码 :2909.50.5000
CS-2408性质、用途与生产工艺
- 生物活性 HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone) 是一种强力的亲脂性酚类抗氧化剂。HTHQ 通过与活性氧 (ROS) 直接反应并清除 ROS 以形成更稳定的自由基而具有很强的抗氧化活性。
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靶点
ROS
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体外研究
HTHQ (0-100 μM; 24 hours; PC12 cells) treatment increases cell viabilities in a dose-dependent manner.
HTHQ (10 μM; 0.6-24 hours; PC12 cells) inhibits 3,4-L-Dihydroxyphenylalanine (L-DOPA) -induced phosphorylation of sustaines extracellular signal-regulated kinases (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK1/2). HTHQ also normalizes L-DOPA-reduced Bcl-2-associated death protein (Bad) phosphorylation and Bcl-2-associated X protein (Bax) expression, promoting cell survival.Cell Viability Assay
Cell Line: PC12 cells Concentration: 0 μM, 1 μM, 10 μM, and 100 μM Incubation Time: 24 hours Result: Reduced cell viability at 24 hours caused by both 100 and 200 µM L-DOPA was significantly attenuated. Western Blot Analysis
Cell Line: PC12 cells Concentration: 10 μM Incubation Time: 0.6-24 hours Result: Inhibited L-DOPA-induced phosphorylation of sustained extracellular signal-regulated kinases (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK1/2). And also normalized L-DOPA-reduced Bcl-2-associated death protein (Bad) phosphorylation and Bcl-2-associated X protein (Bax) expression. -
体内研究
HTHQ (50-200 mg/kg; oral administration; for 4 weeks; specific pathogen-free male Sprague Dawley rats) treatment significantly improves liver weight and serum chemistry level. HTHQ reduces hydroxyproline and malondialdehyde level in the liver. HTHQ treatment also reduces fibrotic septa. HTHQ administration shows reduced mRNA level of PDGF (Plateletderived growth factor) , α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β) than DMN-induced hepetic fibrosis animals in the liver tissue.
Animal Model: 48 specific pathogen-free male Sprague Dawley (SD) rats (6-week-old ) with dimethylnitrosamine (DMN) Dosage: 50 mg/kg, 100 mg/kg, 200 mg/kg Administration: Oral administration; for 4 weeks Result: Improved against DMN-induced liver fibrosis in male SD rats.
- 更新日期：2024/11/08
- 产品编号：H1741
- 产品名称：4-(己氧基)-2,3,6-三甲基苯酚 4-(Hexyloxy)-2,3,6-trimethylphenol
- CAS编号：148081-72-5
- 包装：50mg
- 价格：210元
- 更新日期：2024/11/08
- 产品编号：H1741
- 产品名称：4-(己氧基)-2,3,6-三甲基苯酚 4-(Hexyloxy)-2,3,6-trimethylphenol
- CAS编号：148081-72-5
- 包装：250mg
- 价格：990元
- 公司名称：CHEMICAL LAND21
- 联系电话：--
- 电子邮件：sales21@chemicalland21.com
- 国家：韩国
- 产品数：6303
- 优势度：74
