GSK-3 β inhibitor 2
- CAS号:1702428-31-6
- 英文名:GSK-3 β inhibitor 2
- 中文名:GSK-3 β inhibitor 2
- CBNumber:CB57247236
- 分子式:C14H14N4O3S
- 分子量:318.35
- MOL File:1702428-31-6.mol
- 密度 :1.475±0.06 g/cm3(Predicted)
- 酸度系数(pKa) :13.08±0.20(Predicted)
- 形态 :Solid
- 颜色 :Light yellow to yellow
GSK-3 β inhibitor 2性质、用途与生产工艺
- 生物活性 GSK-3β inhibitor 2 (Compound 3) 是一种有效,选择性和口服活性的 GSK-3β 抑制剂,IC50 为 1.1 nM。GSK-3β inhibitor 2 可以穿越血脑屏障。GSK-3β inhibitor 2 有用于阿尔茨海默氏病的潜力。
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靶点
GSK-3β
1.1 nM (IC 50 )
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体外研究
The pyridine carboxamide of GSK-3β inhibitor 2 (Compound 3) makes hydrogen bonds with the hinge V135 backbone amide, and the carbonyl oxygen of the thiazolyl primary amide formed a critical hydrogen bond with K85. The quality of the electron density for the methyl group of the methoxy moiety in GSK-3β inhibitor 2 does not allow its unambiguous placement in the model, but a small molecule crystal structure of GSK-3β inhibitor 2 determined by single crystal X-ray diffraction method confirmed the intramolecular hydrogen bonding between the methoxy -O- and the amide N-H in GSK-3β inhibitor 2.
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体内研究
The elevation of hyperphosphorylated Tau (pTau) is mimicked in LaFerla 3xTg-C57BL6 mice, and accordingly, these mice are used as an in vivo model of Alzheimer’s disease. GSK-3β inhibitor 2 (Compound 3) shows a significant reduction in pTau396 when administered orally at 30 mg/kg as a nanosuspension to LaFerla 3xTg-C57BL6 male mice. GSK-3β inhibitor 2 shows only modest brain exposure (B/P = 0.26) as determined as a single time point.
- 更新日期:2024/08/19
- 产品编号:HY-130795
- 产品名称:GSK-3 β inhibitor 2 GSK-3β inhibitor 2
- CAS编号:1702428-31-6
- 包装:5mg
- 价格:1750元
- 更新日期:2024/08/19
- 产品编号:HY-130795
- 产品名称:GSK-3 β inhibitor 2 GSK-3β inhibitor 2
- CAS编号:1702428-31-6
- 包装:10mg
- 价格:2800元
- 公司名称:TargetMol Chemicals Inc.
- 联系电话:+1-781-999-5354 +1-00000000000
- 电子邮件:marketing@targetmol.com
- 国家:美国
- 产品数:19892
- 优势度:58
- 公司名称:Aladdin Scientific
- 联系电话:+1-+1(833)-552-7181
- 电子邮件:sales@aladdinsci.com
- 国家:美国
- 产品数:52927
- 优势度:58
- 公司名称:MedChemExpress
- 联系电话:--
- 电子邮件:sales@medchemexpress.com
- 国家:美国
- 产品数:6398
- 优势度:58