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ChemicalBook  CAS数据库列表  L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE

L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE

生物活性 靶点 体外研究 体内研究
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE,159190-45-1,结构式
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
  • CAS号:159190-45-1
  • 英文名:L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
  • 中文名:L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
  • CBNumber:CB5353543
  • 分子式:C8H18ClN3O2
  • 分子量:223.7
  • MOL File:159190-45-1.mol
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE化学性质
  • 储存条件 :-20°C
  • 溶解度 :DMF: 15 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS: 30 mg/mL; Water: 50 mg/ml
  • 形态 :White to off-white solid.
  • 生物来源 :synthetic (organic)
  • 水溶解性 :water: 50mg/mL, clear, colorless
安全信息

L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE性质、用途与生产工艺

  • 生物活性 L-NIL dihydrochloride 是诱导型一氧化氮合成酶 (iNOS) 的抑制剂，其对 miNOS 的 IC50 值为3.3 μM。
  • 靶点

    IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase).

  • 体外研究

    L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC 50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA.

  • 体内研究

    L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice.

    Animal Model: Adult male Balb/c (20-25 g).
    Dosage: 10 and 30 mg/kg.
    Administration: Intraperitoneally at the end of CLP and at 6 h after sepsis induction.
    Result: Led to a negligible increase in plasma NGAL compared to sham mice.
    Led to a significant decrease in both TLR4 and IL1βprotein contents and clusterin transcript.
    Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle.
    Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE上下游产品信息
上游原料
下游产品
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE生产厂家
  • 公司名称：TargetMol Chemicals Inc.
  • 联系电话：+1-781-999-5354 +1-00000000000
  • 电子邮件：marketing@targetmol.com
  • 国家：美国
  • 产品数：32161
  • 优势度：58
  • 公司名称：江苏洪珉药业有限公司
  • 联系电话：18221292452
  • 电子邮件：fannieliu@glschina.com
  • 国家：中国
  • 产品数：6798
  • 优势度：58
  • 公司名称：ChemeGen 中国
  • 联系电话： 18818260767
  • 电子邮件：sales@chemegen.com
  • 国家：中国
  • 产品数：11218
  • 优势度：58
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