盐酸苯氧丙酚胺

盐酸苯氧丙酚胺化学性质

熔点 :203-204°
储存条件 :Inert atmosphere,2-8°C
溶解度 :Sparingly soluble in water and in ethanol (96 per cent), practically insoluble in methylene chloride.
酸度系数(pKa) :pKa 8.0 (Uncertain);9.8 (Uncertain)
形态 :Solid
颜色 :White to off-white
CAS 数据库 :579-56-6(CAS DataBase Reference)

安全信息

盐酸苯氧丙酚胺化学药品说明书

异克舒令|药物应用信息

生物活性 Isoxsuprine hydrochloride是β-肾上腺素能受体（beta-adrenergic）激动剂，具有血管扩张活性。
靶点

Ki: 13.65 μΜ (myometrial beta-adrenergic receptor), 3.48 μΜ (placcntal beta-adrenergic receptor)
NMDA receptor
体外研究

Results show that Isoxsuprine hydrochloride inhibits circular chemorepellent induced defect (CCID) formation dose dependently (5 to 60 μM) and also inhibits 12(S)-HETE synthesis. Furthermore, Isoxsuprine hydrochloride is the only drug inhibiting the induction of all three mobility markers (MLC2, MYPT and paxillin).
体内研究

Total infarct volume in vehicle-treated animals is 279±25 mm ³ compare to 137±18 mm ³ in Isoxsuprine hydrochloride-treated animals.

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