用途 生物活性 靶点 体外研究 体内研究 糠酸氟替卡松 试剂级价格
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糠酸氟替卡松

糠酸氟替卡松,397864-44-7,结构式
糠酸氟替卡松
  • CAS号:397864-44-7
  • 英文名:FLUTICASONE FUROATE
  • 中文名:糠酸氟替卡松
  • CBNumber:CB51509114
  • 分子式:C27H29F3O6S
  • 分子量:538.58
  • MOL File:397864-44-7.mol
糠酸氟替卡松化学性质
  • 熔点 :250-252°C (dec.)
  • 沸点 :625.2±55.0 °C(Predicted)
  • 密度 :1.39
  • 储存条件 :-20°C Freezer
  • 溶解度 :Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly)
  • 酸度系数(pKa) :12.52±0.70(Predicted)
  • 形态 :Solid
  • 颜色 :White to Off-White

糠酸氟替卡松性质、用途与生产工艺

  • 用途

    糠酸氟替卡松为源自氟替卡松的一种人工合成皮质类固醇,可治疗过敏性鼻炎用。

  • 生物活性

    糠酸氟替卡松(GW685698)是一种吸入性皮质类固醇/长效的β肾上腺素能受体激动剂的复方治疗药物,能延长支气管扩张剂的作用时间。它被用于非过敏性和过敏性皮炎的治疗。

  • 靶点

    Kd: 0.3 nM (Corticosteroid)

  • 体外研究

    Fluticasone furoate comes in a nasal spray, as an aqueous suspension of micronized fluticasone furoate for topical administration to the nasal mucosa by means of a metering, atomizing spray pump.
    Fluticasone furonate displays great potency in inhibiting tumor necrosis factor synthesis and action. Fluticasone furonate is also potent in preventing damage to cultured human lung epithelial cells by different stimulus.

  • 体内研究

    Fluticasone furonate is 99.4% bound to plasma protein in vitro and other research indicated extensive first-pass metabolism of the absorbed drug. Protein binding is highly relevant because only the unbound free drug can exert an effect at the receptor site. Clearance of Fluticasone furonate is primarily by hydrolysis in the liver by the cytochrome P450 isozyme (CYP) 3A4 that converts the drug to the 17β-carboxylic acid metabolite (M10), which displays low glucocorticoid receptor agonist potency. Fluticasone furonate is excreted mainly in the feces, with only minor amounts in the urine.

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糠酸氟替卡松 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:HY-15234
  • 产品名称:Fluticasone furoate
  • CAS编号:
  • 包装:5 mg
  • 价格:343元
  • 更新日期:2024/11/08
  • 产品编号:HY-15234
  • 产品名称:糠酸氟替卡松 Fluticasone furoate
  • CAS编号:397864-44-7
  • 包装:10mg
  • 价格:550元
糠酸氟替卡松生产厂家
  • 公司名称:北京百灵威科技有限公司
  • 联系电话:010-82848833 400-666-7788
  • 电子邮件:jkinfo@jkchemical.com
  • 国家:中国
  • 产品数:96815
  • 优势度:76
  • 公司名称:LGM Pharma
  • 联系电话:1-(800)-881-8210
  • 电子邮件:inquiries@lgmpharma.com
  • 国家:美国
  • 产品数:2123
  • 优势度:70
  • 公司名称:T&W GROUP
  • 联系电话:021-61551611 13296011611
  • 电子邮件:contact@trustwe.com
  • 国家:中国
  • 产品数:9895
  • 优势度:58
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