异樱花亭

产品描述生物活性体外研究体内研究异樱花亭试剂级价格

异樱花亭

CAS号:480-43-3
英文名:ISOSAKURANETIN
中文名:异樱花亭
CBNumber:CB5141311
分子式:C16H14O5
分子量:286.28
MOL File:480-43-3.mol

异樱花亭化学性质

熔点 :193-194°C
沸点 :539.2±50.0 °C(Predicted)
密度 :1.370±0.06 g/cm3(Predicted)
溶解度 :DMSO : 125 mg/mL (436.64 mM; Need ultrasonic and warming)
形态 :powder
酸度系数(pKa) :7.50±0.40(Predicted)
颜色 :White
LogP :3.840 (est)

安全信息

危险类别码 :22
安全说明 :22-45
海关编码 :29329990

异樱花亭性质、用途与生产工艺

产品描述异樱花亭是一种白色针晶(氯仿-甲醇)，溶于氯仿、甲醇、丙酮、乙酸乙酯、DMSO。紫外灯365nm下显绿色荧光，盐酸镁粉反应呈阳性，浓硫酸-香草醛反应显橙红色。
生物活性 Isosakuranetin 是可以在 Citrus bergamia 的果实中找到的黄烷酮黄酮类化合物。
体外研究

Isosakuranetin stimulates melanin accumulation in a dose-dependent manner. In addition, Isosakuranetin at 30 μM gradually increases the expression of Tyr, TRP1, and TRP2 after 48 and 72 h. The MTT assay shows that Isosakuranetin decreases the number of cells at concentrations greater than 45 μM. Further analysis of trypan blue staining demonstrates that Isosakuranetin does not affect the viability of B16 melanocytes, but shows that Isosakuranetin decreases their proliferation rate. The tyrosinase activity of B16 melanocytes treated with 15 and 30 μM Isosakuranetin for 72 h is significantly increased by 2- and 3.2-fold, respectively, in comparison with that of the control cells.
体内研究

Isosakuranetin dose-dependently increases the paw-withdrawal threshold within the dose range of 1.5 to 6 mg/kg. Post hoc analysis reveals that Isosakuranetin increases the paw-withdrawal threshold and statistical significance is seen at times 30 and 40 min for the dose of 3 mg/kg and 30 to 60 min for the dose of 6 mg/kg.
化学性质黄色结晶性粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于飞机草，蔷薇科樱属植物樱花Prunus serrulata。
用途用于含量测定/鉴定/药理实验等。