ChemicalBook CAS数据库列表 Pep2m, myristoylated
Pep2m, myristoylated
- CAS号:1423381-07-0
- 英文名:Pep2m, myristoylated
- 中文名:Pep2m, myristoylated
- CBNumber:CB42518729
- 分子式:C63H118N18O14S
- 分子量:1383.81
- MOL File:1423381-07-0.mol
Pep2m, myristoylated化学性质
- 密度 :1.32±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 酸度系数(pKa) :3.25±0.10(Predicted)
- 水溶解性 :Soluble to 1 mg/ml in sterile water
Pep2m, myristoylated性质、用途与生产工艺
- 生物活性 Pep2m, myristoylated (Myr-Pep2m) 是一种细胞通透性肽。Pep2m, myristoylated (Myr-Pep2m) 能破坏蛋白激酶 ζ (PKMζ) 下游靶点 NSF/GluR2 相互作用。PKMζ 具有自主活性的 PKC 同工酶。
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靶点
NSF/GluR2 interactions
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体外研究
Pep2m, myristoylated (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation.
Pep2m, myristoylated does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis.
Pep2m, myristoylated blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture.
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体内研究
Pep2m, myristoylated (10 µg) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test.
Animal Model: Female and male Long-Evans hooded rats (8 weeks) Dosage: 10 µg (in 20 µL) Administration: Intrathecal injection Result: Resulted in an increase in PWTs, in both male and female rats at various time points tested.
Pep2m, myristoylated上下游产品信息
上游原料
下游产品
Pep2m, myristoylated生产厂家
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
