ChemicalBook CAS数据库列表 BIX 01294
BIX 01294
- CAS号:935693-62-2
- 英文名:BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride
- 中文名:BIX 01294
- CBNumber:CB42095439
- 分子式:C28H38N6O2
- 分子量:490.64
- MOL File:935693-62-2.mol
BIX 01294化学性质
- 沸点 :654.6±65.0 °C(Predicted)
- 密度 :1.195±0.06 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :Soluble in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml).
- 酸度系数(pKa) :9.34±0.70(Predicted)
- 形态 :Off-white solid
- 颜色 :Off-white
- 稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
- InChIKey :BZOWJAYUMMHCDW-UHFFFAOYSA-N
BIX 01294性质、用途与生产工艺
- 生物活性 BIX-01294 是一种 G9a 组蛋白甲基转移酶 (G9a Histone Methyltransferase) 抑制剂，IC50 值为 1.9 μM。
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靶点
IC50: 1.9 μM (G9a Histone Methyltransferase)
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体外研究
BIX-01294 (4.1 μM) treatment of G9anull ES cells results in a further reduction in H3K9me2 levels. BIX-01294 reduces H3K9me2 at several G9a target genes.
BIX-01294 (5 µM) reduces levels of global H3K9 methylation in pronuclear- and 2-cell-stage embryos. Embryos transiently exposed to BIX-01294 have a reduced ability to establish pregnancy.
BIX-01294 (1 µg/mL) causes reduction in the BrdU incorporation of fetal PASMCs. BIX-01294 treatment decreases the PASMCs migration induced by PDGF.
BIX 01294上下游产品信息
上游原料
下游产品
BIX 01294 试剂级价格
- 更新日期：2024/11/08
- 产品编号：46783
- 产品名称：BIX-01294, 95% BIX-01294, 95%
- CAS编号：935693-62-2
- 包装：100mg
- 价格：3930元
- 更新日期：2024/11/08
- 产品编号：HY-10587
- 产品名称：BIX-01294
- CAS编号：
- 包装：1 mg
- 价格：327元
BIX 01294生产厂家
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
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