ChemicalBook CAS数据库列表 Isofagomine D-Tartrate
Isofagomine D-Tartrate
- CAS号:957230-65-8
- 英文名:Isofagomine D-Tartrate
- 中文名:Isofagomine D-Tartrate
- CBNumber:CB41873108
- 分子式:C10H19NO9
- 分子量:297.26
- MOL File:957230-65-8.mol
Isofagomine D-Tartrate化学性质
- 熔点 :124-126°C
- 储存条件 :-20°C Freezer, Under Inert Atmosphere
- 溶解度 :Soluble in DMSO (up to 2 mg/ml)
- 形态 :solid
- 颜色 :Off-white
- 稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Isofagomine D-Tartrate性质、用途与生产工艺
- 生物活性 Afegostat D-Tartrate 是一种药理学伴侣，高亲和力且特异性和可逆地结合内质网 (ER) 中的酸性 β-葡萄糖苷酶 (GCase)。
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靶点
GCase
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体内研究
Vivo: Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates.
Isofagomine D-Tartrate上下游产品信息
上游原料
下游产品
Isofagomine D-Tartrate生产厂家
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
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