六氢姜黄素
- CAS号:36062-05-2
- 英文名:HEXAHYDROCURCUMIN
- 中文名:六氢姜黄素
- CBNumber:CB41412369
- 分子式:C21H26O6
- 分子量:374.43
- MOL File:36062-05-2.mol
- 熔点 :80-82℃
- 沸点 :622.6±55.0 °C(Predicted)
- 密度 :1.226
- 闪点 :218℃
- 储存条件 :2-8°C
- 溶解度 :Chloroform (Sparingly), Ethyl Acetate (Slightly), DCM, DMSO
- 形态 :Solid
- 酸度系数(pKa) :10.02±0.20(Predicted)
- 颜色 :Pale Yellow
- BRN :2486876
- WGK Germany :3
六氢姜黄素性质、用途与生产工艺
- 生物活性 Hexahydrocurcumin 是姜黄素的主要代谢产物之一,是一种选择性的口服活性 COX-2 抑制剂,对 COX-1 无活性。Hexahydrocurcumin 具有抗氧化,抗癌和抗炎的作用。
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靶点
COX-2
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体外研究
Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) treatment significantly decreased the viability of HT-29 colon cancer cells in a time- and concentration-dependent. The respective IC 50 values for 24 and 48 h of Hexahydrocurcumin exposureare 77.05 and 56.95, respectively.
Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 µM) markedly reduces the COX-2 expression. The level of COX-1 is not altered.
Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 µM) markedly reduces the COX-2 protein. The level of COX-1 protein is not altered.
Hexahydrocurcumin (7-14 μM; 24 hours) attenuates lipopolysaccharide (LPS)-elicited increase of prostaglandin E 2 (PGE 2 ) in murine macrophages (RAW 264.7) in a concentration-dependent manner.Cell Viability Assay
Cell Line: HT-29 cells Concentration: 0 µM, 5 µM, 10 µM, 25 µM Incubation Time: 24 hours or 48 hours Result: Significantly decreased the viability of HT-29 colon cancer cells. RT-PCR
Cell Line: HT-29 cells Concentration: 25 µM Incubation Time: 24 hours Result: Combined with 5-fluorouracil (5-FU; 5 µM) markedly reduced the COX-2 expression. Western Blot Analysis
Cell Line: HT-29 cells Concentration: 25 µM Incubation Time: 24 hours Result: Combined with 5-fluorouracil (5-FU; 5 µM) markedly reduced the COX-2 protein. -
体内研究
Hexahydrocurcumin (50 mg/kg; oral administration; daily; for 16 weeks; male Wistar rats) treatment significantly reduces the numbers of aberrant crypt foci (ACF) in colon cancer rats. Hexahydrocurcumin also markedly decreases COX-2 protein expression. The levels of COX-1 protein is not different from normal rats.
Animal Model: Male Wistar rats (100-120 g) injected with dimethylhydrazine (DMH) Dosage: 50 mg/kg Administration: Oral administration; daily; for 16 weeks Result: Significantly reduced the numbers of ACF in colon cancer rats. Also markedly decreased COX-2 protein expression.
- 更新日期:2024/11/08
- 产品编号:HY-N0929
- 产品名称:Hexahydrocurcumin
- CAS编号:
- 包装:1 mg
- 价格:1309元
- 更新日期:2024/11/08
- 产品编号:HY-N0929
- 产品名称:六氢姜黄素 Hexahydrocurcumin
- CAS编号:36062-05-2
- 包装:5mg
- 价格:3600元
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