NEUROPEPTIDE S (HUMAN)

生物活性靶点体外研究体内研究 NEUROPEPTIDE S (HUMAN) 试剂级价格

CAS号:412938-67-1
英文名:NEUROPEPTIDE S (HUMAN)
中文名:NEUROPEPTIDE S (HUMAN)
CBNumber:CB4106928
分子式:C93H155N31O28S
分子量:2187.48
MOL File:412938-67-1.mol

NEUROPEPTIDE S (HUMAN)化学性质

密度 :1.49±0.1 g/cm3(Predicted)
形态 :Solid
颜色 :White to off-white

NEUROPEPTIDE S (HUMAN)性质、用途与生产工艺

生物活性 Neuropeptide S human 是有效的内源性 neuropeptide S receptor 激动剂 (EC50=9.4 nM)。Neuropeptide S human (TFA) 可提高小鼠的运动活性和清醒性。Neuropeptide S human 有潜力用于阿尔茨海默症 (AD) 的研究。
靶点

EC50: 9.4 nM (neuropeptide S receptor)
体外研究

Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC ₅₀ of 6.7 ± 2.4 nM, the binding of [ ^125I ] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (K _d = 0.33 ± 0.12 nM). Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [ ^125I I] Y10-NPS, [ ^125I I] Y10-NPS is displaceable by increasing concentrations of human NPS (IC ₅₀ = 0.42 ± 0.12 nM).

体内研究

Neuropeptide S human (0.1 nM-1 nM; i.c.v.) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice.

Animal Model:	Male C57Bl/6 mice
Dosage:	0.1 nM, 1 nM
Administration:	Intracerebroventricular (i.c.v.) injection
Result:	Increased locomotor activity and promoted wakefulness.