心钠肽

生物活性靶点体外研究

心钠肽化学性质

密度 :1.54±0.1 g/cm3(Predicted)
储存条件 :-20°C
溶解度 :0.05 M acetic acid: 1 mg/mL, clear, colorless
形态 :Solid
颜色 :White to off-white
水溶解性 :Soluble to 1 mg/ml in water
序列 :H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH(Disulfide bridge: Cys7-Cys23)

安全信息

心钠肽性质、用途与生产工艺

生物活性 Atrial Natriuretic Peptide (ANP) (1-28), rat 是心房利钠肽 (ANP) 在大鼠中的主要循环形式，强效抑制血管紧张素 II (Ang II)-刺激的内皮素-1 (endothelin-1) 分泌。
靶点

Endothelin-1
体外研究

Rat ANP (1-28) and rat BNP-45, which are the respective major circulating forms of ANP and BNP in rats, potently inhibited Ang II-stimulated endothelin-1 secretion in a concentration-dependent manner. Rat ANP (5-25) is less effective that Rat ANP(1-28) with respect to inhibiting immunoreactive (ir)-endothelin-1 secretion and increasing cellular cyclic GMP. Rat ANP (1-28) inhibits the secretion of ir-endothelin-1 in a concentration-dependent manner between 0.01 and 1 μM.
参考质量标准外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%

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心钠肽生产厂家

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