ChemicalBook CAS数据库列表 JC-171
(JC171)
JC-171 (JC171)
- CAS号:2112809-98-8
- 英文名:JC-171 (JC171)
- 中文名:JC-171 (JC171)
- CBNumber:CB34844922
- 分子式:C16H17ClN2O5S
- 分子量:384.83
- MOL File:2112809-98-8.mol
JC-171
(JC171)化学性质
- 密度 :1.401±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: 250 mg/mL (649.64 mM)
- 形态 :Solid
- 酸度系数(pKa) :6.43±0.69(Predicted)
- 颜色 :White to off-white
JC-171 (JC171)性质、用途与生产工艺
- 生物活性 JC-171 是选择性的 NLRP3 炎症小体抑制剂,抑制 LPS/ATP 诱导的巨噬细胞释放 IL-1β 的 IC50 值为 8.45 μM。
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体外研究
JC-171 (0-100 μM) blocks NLRP3 inflammasome activation and IL-1β production in primary macrophages dose dependently.
Cell Viability Assay
Cell Line: J774A.1 murine macrophage cells Concentration: 0-100 μM. Incubation Time: 0.5 h (before LPS (1 μg/mL) treatment for 4.5 h). Result: Inhibited the release of IL-1β in J774A.1 cells upon stimulation with LPS/ATP. -
体内研究
JC-171 treatment delays the progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE) in mouse.
Animal Model: Mice immunized subcutaneously with 200 μg Myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide emulsified in Complete Freund’s Adjuvant (CFA) on day 0 followed by injection of 200 ng of pertussis toxin. Dosage: 100 mg/kg, 10 mg/kg. Administration: IP days 0, 1 and 2; and every other days thereafter (100 mg/kg).
Initiated when the clinical scores of individual mice have reached 1 (flaccid tail), and given every other day (10 mg/kg).
Result: Efficiently suppressed EAE progression compared with vehicle treatment.
Resulted in a substantial decrease in the frequency of MOG 35–55 -specific Th17 cells in the spleens and spinal cords of EAE mice.
JC-171
(JC171)上下游产品信息
上游原料
下游产品
JC-171
(JC171)生产厂家
- 公司名称:Aladdin Scientific
- 联系电话:+1-+1(833)-552-7181
- 电子邮件:sales@aladdinsci.com
- 国家:美国
- 产品数:52927
- 优势度:58
- 公司名称:MedChemExpress
- 联系电话:--
- 电子邮件:sales@medchemexpress.com
- 国家:美国
- 产品数:6398
- 优势度:58