头孢唑啉

生物活性靶点体外研究体内研究头孢唑啉试剂级价格

头孢唑啉

CAS号:25953-19-9
英文名:Cefazolin
中文名:头孢唑啉
CBNumber:CB3396249
分子式:C14H14N8O4S3
分子量:454.51
MOL File:25953-19-9.mol

头孢唑啉化学性质

熔点 :198-200 C
密度 :2.01±0.1 g/cm3(Predicted)
储存条件 :Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度 :DMSO (Slightly), Methanol (Very Slightly, Heated)
酸度系数(pKa) :pKa 2.15 (Uncertain)
颜色 :White to Off-White
稳定性 :Hygroscopic
CAS 数据库 :25953-19-9(CAS DataBase Reference)

安全信息

危险品标志 :Xn
危险类别码 :20/21/22-36/37/38
安全说明 :26-36
WGK Germany :3
海关编码 :2941906000
毒害物质数据 :25953-19-9(Hazardous Substances Data)
毒性 :mouse,LD50,intramuscular,4gm/kg (4000mg/kg),Byoin Yakugaku. Hospital Pharmacology. Vol. 3, Pg. 220, 1978.

头孢唑啉 MSDS

Cefazolin

头孢唑啉化学药品说明书

头孢唑林钠原料药—头孢唑林—高效液相色谱法|药物分析方法信息

头孢唑啉性质、用途与生产工艺

生物活性 Cefazolin是一种半合成的头孢菌素，具有广谱的抗菌作用，抑制细菌细胞壁的合成。它可达到高血清水平，通过尿液快速排泄。
靶点

Antibiotic

体外研究

Cefazolin (50-300 μg/mL; 6 or 24 hours) has a direct anti-inflammatory effect on C8-B4 cells stimulated by LPS (1 μg/mL).

Cell Viability Assay

Cell Line:	Mouse C8-B4 microglial cells
Concentration:	50, 100, 150, 200, 250, and 300 μg/mL
Incubation Time:	6 or 24 hours
Result:	Inhibited proinflammatory cytokine production. Inhibited IL-6 production at 50 and 100 μg/mL.

体内研究

Cefazolin (300 mg/kg; injected intraperitoneally 1 h before surgery and then once per day for 5 days after surgery) can attenuate surgery-induced post-operative memory and learning impairment in mice. Cefazolin alone may induce cognitive dysfunction possibly by transient gut dysbiosis in mice without surgery.

Animal Model:	Six- to 8-week-old CD-1 male mice (weighing 31-36 g)
Dosage:	300-500 mg/kg
Administration:	10 mg in 0.1 mL was intraperitoneally injected 30 min before surgery and then once every day for 5 days.
Result:	Improved learning and memory after surgery and might impair learning and memory in mice without surgery.

化学性质针状晶体。熔点198-200℃（分解），易溶于DMF、吡啶，溶于丙酮、乙醇，微溶于甲醇，不溶于氯仿、苯、醚。其钠盐（[27164-46-1]）为白色或微黄色粉末。难溶于甲醇、乙醇，不溶于丙酮、氯仿。干燥时稳定，水溶液的稳定性较差。
用途半合成广谱头孢菌素。抗菌机理、抗菌谱、适应症均与头孢噻吩相似。对革兰氏性菌弱于后者。但对革兰氏阴性菌比后者强得多，尤其对肺炎杆菌有效，对大肠杆菌比头孢噻吩强，对肺炎球菌作用仅次于青霉素而优于其他抗生素。血清蛋白结合率74-86%。在肝、肾、心、脾、肺、肌肉等组织中浓度高。用于上述器官敏感菌感染。特别是用于一些严重感染。临床治疗呼吸系统及泌尿系感染疗效显著。
用途为半合成广谱头孢菌素，抗菌机理、抗菌谱、适应性均与头孢噻吩相似
生产方法以头孢菌素C为原料制得。