GW501516
- CAS号:317318-70-0
- 英文名:GW-501516
- 中文名:GW501516
- CBNumber:CB31476045
- 分子式:C21H18F3NO3S2
- 分子量:453.5
- MOL File:317318-70-0.mol
- 熔点 :134-136°C
- 沸点 :584.5±60.0 °C(Predicted)
- 密度 :1.42±0.1 g/cm3(Predicted)
- 储存条件 :-20°C
- 溶解度 :DMSO: soluble20mg/mL, clear
- 形态 :powder
- 酸度系数(pKa) :3.17±0.10(Predicted)
- 颜色 :white to beige
- BRN :18515150
- 稳定性 :Light Sensitive
- InChI :InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
- InChIKey :YDBLKRPLXZNVNB-UHFFFAOYSA-N
- SMILES :C(O)(=O)COC1=CC=C(SCC2SC(C3=CC=C(C(F)(F)F)C=C3)=NC=2C)C=C1C
- CAS 数据库 :317318-70-0
- WGK Germany :3
- RTECS号 :AI9105500
GW501516性质、用途与生产工艺
- 生物活性 GW 501516 (GW 1516) 是 PPARδ 的激动剂，EC50 值为 1.1 nM。
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靶点
Target Value PPARδ
(Cell-free assay)1 nM(Ki) -
体外研究
GW 501516 is shown to be the most potent and selective PPARα agonists known with an EC 50 of 1.1 nM against PPARα and 1000-fold selectivity over the other human subtypes, PPARα and-γ. GW 501516 exerts anti-inflammatory effects in mouse cultured proximal tubular (mProx) cells. GW 501516 inhibits palmitate- and TNFα-induced increases in MCP-1 mRNA expression in a dose-dependent manner.
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体内研究
GW 501516 causes impaired bone formation, leading to decreased BMD and deterioration of bone properties in OVX rats. GW 501516 attenuates interstitial inflammation and proximal tubular cell damage in a protein-overload mouse nephropathy model. GW 501516 treatment enhances running endurance and the proportion of succinate dehydrogenase (SDH)-positive muscle fibres in both trained and untrained mice.
- 更新日期：2024/11/08
- 产品编号：S1473
- 产品名称：GW501516 GW501516
- CAS编号：317318-70-0
- 包装：5mg
- 价格：2205.27元
- 更新日期：2024/11/08
- 产品编号：S1473
- 产品名称：GW501516 GW501516
- CAS编号：317318-70-0
- 包装：25mg
- 价格：7945.88元
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
